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To investigate their roles in tooth movement, root resorption, and repair, the occurrence of components of the IGF system, including the ligands IGF\u2010I and \u2010II, the IGF receptor 1 (IGF1R) and six IGF\u2010binding proteins (IGFBP\u20101 to \u20106), was investigated by immunohistochemistry on sections from rat maxillae where the first molar had been moved mesially by means of an orthodontic appliance for 9\u2003d to induce root resorption. After force deactivation on day 0, early repair was studied after a further 5, 7, 10, 12, 14, and 17\u2003d. The immunostaining pattern in the periodontal ligament, cementum, and bone of control animals showed similarities known from studies in human teeth. Increased immunostaining for nearly all components in pressure sides and resorption lacunae indicated an involvement in resorption processes and clastic activities. During early stages of repair, the occurrence of several components (e.g. IGF\u2010II, IGFBP\u20105 or \u20106) within lacunae and in cementoblasts showed an involvement in the resorption\u2010repair sequence, which is considered to be a coupling process as known from bone.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00381.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T09:54:28Z","timestamp":1284544468000},"page":"318-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Insulin\u2010like growth factor system components in the periodontium during tooth root resorption and early repair processes in the rat"],"prefix":"10.1111","volume":"114","author":[{"given":"Werner","family":"G\u00f6tz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Kunert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshar","family":"Kawarizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Lossd\u00f6rfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"117","volume-title":"Orthodontics: current principles and techniques","author":"Thilander B","year":"2000"},{"key":"e_1_2_6_3_2","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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