{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:10:40Z","timestamp":1781284240095,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Tooth eruption requires alveolar bone resorption and bone formation. The coronal half of the dental follicle probably mediates the bone resorption seen in the coronal region of the alveolar bony crypt, and the basal half of the follicle mediates bone growth in the basal region. We hypothesized that the expression of a gene for bone resorption \u2013 receptor activator of nuclear factor kappa B ligand (RANKL) \u2013 would be higher in the coronal than in the basal region of the follicle. Conversely, the level of expression of bone morphogenetic protein\u20102 (BMP\u20102), a gene for bone formation, would be higher in the basal region. Results obtained using laser\u2010capture microdissection and real\u2010time reverse transcription\u2013polymerase chain reaction (RT\u2013PCR) confirmed the hypothesis. Scanning electron micrographs of the bony crypt showed that the coronal area of the crypt was scalloped in appearance (bone resorption), whereas the basal area was trabecular (bone formation). Thus, the differences in bone activity at opposite poles of the crypt appear to be caused by differences in the regional expression of genes in the dental follicle and suggest a molecular mechanism whereby the dental follicle could regulate both the alveolar bone resorption and formation needed for eruption.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00406.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T13:42:43Z","timestamp":1165412563000},"page":"512-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Regional differences of expression of bone morphogenetic protein\u20102 and RANKL in the rat dental follicle"],"prefix":"10.1111","volume":"114","author":[{"given":"Gary 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