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Numerous multinucleated osteoclasts were distributed throughout the mandible in 5\u2010wk\u2010old <jats:italic>c\u2010src<\/jats:italic> KO mice, but by 14\u2003wk they had almost completely disappeared from the alveolar bone, leaving tartrate\u2010resistant acid phosphatase (TRAP)\u2010positive layers along the bone surface. Deposition of osteopontin\u2010positive mineralized tissue, reminiscent of acellular afibrillar cementum (AAC), was confirmed along the TRAP\u2010positive bone surface at 14\u2003wk. The layer progressively thickened up to 21\u2003months. A comparable mineralized layer was noted along the trabeculae of long bones as thickened cement lines. In the periostin\u2010rich areas of jaw bones, but not in the long bones, portions of AAC\u2010like mineralized layers were often replaced with and\/or covered by acellular extrinsic fiber cementum (AEFC)\u2010like tissue. These data suggest that the deposition of AAC\u2010like mineralized tissue is a general phenomenon that may occur along inert or slowly remodeling bone surfaces under conditions characterized by reduced bone\u2010resorbing activity, whereas the induction of AEFC\u2010like tissue seems to be associated with the expression of certain molecules that are particularly abundant in the microenvironment of the periodontal ligament.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2006.00408.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T13:42:43Z","timestamp":1165412563000},"page":"524-534","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formation of acellular cementum\u2010like layers, with and without extrinsic fiber insertion, along inert bone surfaces of aging <i>c\u2010Src<\/i> gene knockout 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