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Adult ferrets were prepared under anesthesia to allow tooth pulp stimulation, recording from the digastric muscle, and intravenous injections at a subsequent experiment. In some animals, pulpal inflammation was induced by introducing human caries into a deep buccal cavity. After 5\u2003d, animals were re\u2010anaethetized, and the teeth were stimulated at 10 times the threshold of the jaw\u2010opening reflex. Stimulation of all tooth pulps induced ipsilateral Fos in the trigeminal subnuclei caudalis and oralis. All non\u2010stimulated animals showed negligible Fos labeling, with no differences recorded between inflamed and non\u2010inflamed groups. Following tooth pulp stimulation, Fos expression was greater in animals with inflamed teeth than in animals with non\u2010inflamed teeth, with the greatest effect seen in the subnucleus caudalis. These results suggest that inflammation increases the number of trigeminal brainstem neurons activated by tooth pulp stimulation; this may be mediated by peripheral or central mechanisms.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2007.00411.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T23:39:50Z","timestamp":1171409990000},"page":"40-47","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of inflammation on Fos expression in the ferret trigeminal nucleus"],"prefix":"10.1111","volume":"115","author":[{"given":"Matthew A.","family":"Worsley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley L.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick 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