{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:02Z","timestamp":1787015042652,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    Periodontitis is a chronic inflammatory disease that affects the tooth supporting tissues. Gingival fibroblasts are the most abundant cells in periodontal tissues and participate actively in the host inflammatory response to periodontopathogens, which is known to mediate local tissue destruction in periodontitis. The aim of this study was to investigate the effect of a proanthocyanidin\u2010enriched cranberry fraction, prepared from cranberry juice concentrate, on inflammatory mediator production by gingival fibroblasts stimulated by the lipopolysaccharide (LPS) of\n                    <jats:italic>Aggregatibacter\u2003actinomycetemcomitans<\/jats:italic>\n                    . Interleukin (IL)\u20106, IL\u20108, and prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) production by fibroblasts treated with the cranberry fraction and stimulated by\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    LPS was evaluated by enzyme\u2010linked immunosorbent assay. Changes induced by\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    LPS and the cranberry fraction in the expression and phosphorylation state of fibroblast intracellular signaling proteins were characterized by antibody microarrays. The LPS\u2010induced IL\u20106, IL\u20108, and PGE\n                    <jats:sub>2<\/jats:sub>\n                    responses of gingival fibroblasts were inhibited by treatment with the cranberry fraction. This fraction was found to inhibit fibroblast intracellular signaling proteins, a phenomenon that may lead to a down\u2010regulation of activating protein\u20101 activity. Cranberry components also reduced cyclooxygenase 2 expression. This study suggests that cranberry juice contains molecules with interesting properties for the development of new host\u2010modulating therapeutic strategies in the adjunctive treatment of periodontitis.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0722.2007.00415.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T18:39:50Z","timestamp":1171391990000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Cranberry components inhibit interleukin\u20106, interleukin\u20108, and prostaglandin E\n                    <sub>2<\/sub>\n                    production by lipopolysaccharide\u2010activated gingival 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