{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:34:18Z","timestamp":1760888058487},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Alteration of the phospholipid (PL) and triglyceride (TG) fatty acid pattern was recently documented in several organs of rats depleted in long\u2010chain polyunsaturated <jats:italic>\u03c9<\/jats:italic>3 fatty acid (<jats:italic>\u03c9<\/jats:italic>3 rats). This study extends such a knowledge to the submandibular gland. The total PL and TG content of the salivary gland was not different in control and <jats:italic>\u03c9<\/jats:italic>3 rats. The sole <jats:italic>\u03c9<\/jats:italic>3 fatty acids found in <jats:italic>\u03c9<\/jats:italic>3 rats (C22:5<jats:italic>\u03c9<\/jats:italic>3 and C22:6<jats:italic>\u03c9<\/jats:italic>3) were present at levels 3\u201312 times lower than in control rats. The C22:5<jats:italic>\u03c9<\/jats:italic>3\/C22:6<jats:italic>\u03c9<\/jats:italic>3 ratio was increased threefold in <jats:italic>\u03c9<\/jats:italic>3 rats. The PL and TG C16:0\/C16:1<jats:italic>\u03c9<\/jats:italic>7 and C18:0\/C18:1<jats:italic>\u03c9<\/jats:italic>9 ratios were decreased in <jats:italic>\u03c9<\/jats:italic>3 rats. The conversion of C18:2<jats:italic>\u03c9<\/jats:italic>6 to C20:4<jats:italic>\u03c9<\/jats:italic>6 and C22:4<jats:italic>\u03c9<\/jats:italic>6 appeared facilitated in the <jats:italic>\u03c9<\/jats:italic>3 rats. Some of these rats were injected intravenously, 60\u2013120\u2003min before killing, with either a medium\u2010chain triglyceride:fish oil emulsion or a control medium\u2010chain triglyceride:olive oil emulsion. The former emulsion increased the PL C22:5<jats:italic>\u03c9<\/jats:italic>3 and C22:6<jats:italic>\u03c9<\/jats:italic>3 content and prevented the age\u2010related decrease in C16:0\/C16:1<jats:italic>\u03c9<\/jats:italic>7 and C18:0\/C18:1<jats:italic>\u03c9<\/jats:italic>9 ratios otherwise also recorded in PL. In conclusion, these findings document an increased activity of \u03949\u2010desaturase, a more efficient conversion of C18:2<jats:italic>\u03c9<\/jats:italic>6 to its metabolites, and an impaired generation of C22:6<jats:italic>\u03c9<\/jats:italic>3 from C22:5<jats:italic>\u03c9<\/jats:italic>3 in <jats:italic>\u03c9<\/jats:italic>3 rats.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2007.00427.x","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T18:49:50Z","timestamp":1178218190000},"page":"103-110","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Altered fatty acid pattern of phospholipids and triglycerides in the submandibular gland of <i>\u03c9<\/i>3\u2010depleted rats"],"prefix":"10.1111","volume":"115","author":[{"given":"Christine","family":"Delporte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy 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