{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:25:13Z","timestamp":1770146713974,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T00:00:00Z","timestamp":1252972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>We tested 65, 44, and 116 patients with oral squamous cell cancer (OSCC), oral leukoplakia (OL), and oral lichen planus (OLP) against 68 age\u2010matched controls for the presence of Epstein\u2013Barr virus (EBV). Apparently healthy mucosa was simultaneously sampled and examined in all patients. Paraffin\u2010embedded tissue sections of all EBV\u2010positive patients with OSCC were examined for latent membrane protein\u20101 (LMP\u20101) expression (demonstrable in most EBV\u2010associated malignancies) using immunohistochemistry. The prevalence of EBV in the controls and in OSCC, OL, and OLP lesions was 19.1%, 73.8%, 29.5%, and 46.6%, respectively, and 66.2%, 22.7%, and 31.9% in the healthy mucosa of patients, respectively. The prevalence of EBV in OSCC patients was significantly higher than in controls or in respective samples of the other two patient groups both in the lesion and in the healthy mucosa. Comparisons including only patients with EBV\u2010negative lesions yielded similar results. Lesions of patients with OLP, but not of patients with OL, differed significantly from controls in EBV prevalence. In OSCC, LMP\u20101 expression was not detected, and EBV carriage was not significantly associated with any risk factors and did not influence the outcome. Although a high prevalence of EBV was found in OSCC, comparable carriage rates on healthy mucosa of patients indicated that an aetiological role of EBV is unlikely.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2009.00660.x","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T10:32:34Z","timestamp":1253010754000},"page":"536-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Epstein\u2013Barr virus prevalence in oral squamous cell cancer and in potentially malignant oral disorders in an eastern Hungarian 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