{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:36:04Z","timestamp":1770352564568,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:00:00Z","timestamp":1257984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>A new spontaneous mouse mutant (<jats:italic>ntl<\/jats:italic>) with autosomal\u2010recessive osteopetrosis was characterized. These mice formed tartrate\u2010resistant acid phosphate (TRAP)\u2010positive osteoclasts but their osteoclasts had no ruffled border and did not resorb bone. These mice displayed no tooth eruption or tooth root formation. Adult mutant mice developed odontoma\u2010like proliferations near the proximal ends of the incisors. Intraperitoneal injection of progenitor cells from the liver of 16.5 days postcoitum wild\u2010type embryos into newborn mutants rescued the osteopetrosis phenotype, indicating that the defects were intrinsic to the osteoclasts. Our findings not only provide further support for a critical role of osteoclasts in tooth eruption and tooth root development, but also suggest that the perturbation of the homeostasis of the odontogenic precursors of the incisors is primarily responsible for the development of the odontoma\u2010like proliferations in this osteopetrosis mutant. Genetic mapping has narrowed down the location of the mutant allele to a genetic interval of 3.2\u2003cM on mouse chromosome 17.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2009.00690.x","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T17:45:33Z","timestamp":1258047933000},"page":"625-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A new osteopetrosis mutant mouse strain <i>(ntl)<\/i> with odontoma\u2010like proliferations and lack of tooth roots"],"prefix":"10.1111","volume":"117","author":[{"given":"Xincheng","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector 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