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Journal compilation \u00a9 2010 Eur J Oral Sci<\/jats:italic><\/jats:p><jats:p>Catechins (bioactive polyphenols in green tea) are known to exhibit potent anti\u2010inflammatory properties. However, the anti\u2010inflammatory effects of catechins on inflamed dental pulp tissue are not known. In this study, we investigated the effect of epigallocatechin\u20103\u2010gallate (EGCG) and epicatechin gallate (ECG), the major components of green tea catechins, on the expression of pro\u2010inflammatory cytokines and adhesion molecules in human dental pulp cells stimulated with bacteria\u2010derived factors such as lipopolysaccharide (LPS) and peptidoglycan (PG). The expression of interleukin (IL)\u20106 and of IL\u20108 was examined using the reverse transcription\u2013polymerase chain reaction and enzyme\u2010linked immunosorbent assays. The expression of intercellular adhesion molecule\u20101 (ICAM\u20101) and of vascular cell adhesion molecule\u20101 (VCAM\u20101) on dental pulp cells was analyzed using flow cytometry. The presence of EGCG and ECG significantly reduced, in a concentration\u2010dependent manner, the expression of IL\u20106 and IL\u20108 in dental pulp cells exposed to LPS or PG. Increased expression of ICAM\u20101 and VCAM\u20101 on the dental pulp cells in response to bacterial components was also decreased by treatment with EGCG and ECG. These findings suggest that green tea catechins may prevent the exacerbation of pulpitis.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2010.00714.x","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T09:57:50Z","timestamp":1268301470000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Anti\u2010inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria\u2010derived 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