{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:13:04Z","timestamp":1773673984215,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T00:00:00Z","timestamp":1268265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p> <jats:italic>Passafaro D, Reina S, Sterin\u2010Borda L, Borda E. Cholinergic autoantibodies from primary Sj\u00f6gren\u2019s syndrome modulate submandibular gland Na<\/jats:italic>\n          <jats:sup>\n            <jats:italic>+<\/jats:italic>\n          <\/jats:sup>\n          <jats:italic>\/K<\/jats:italic>\n          <jats:sup>\n            <jats:italic>+<\/jats:italic>\n          <\/jats:sup>\n          <jats:italic>\u2010ATPase<\/jats:italic>\n          <jats:italic>activity via prostaglandin E<\/jats:italic>\n          <jats:sub>\n            <jats:italic>2<\/jats:italic>\n          <\/jats:sub>\n          <jats:italic>and cyclic AMP. Eur J Oral Sci 2010; 118: 131\u2013138. \u00a9 2010 The Authors. Journal compilation \u00a9 2010 Eur J Oral Sci<\/jats:italic> <\/jats:p><jats:p>We demonstrate that patients with primary Sj\u00f6gren\u2019s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M<jats:sub>3<\/jats:sub> muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial muscarinic agonist, increasing prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) and cyclic AMP production through modifying Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase activity, but also interfere with the secretory effect of the parasympathetic neurotransmitter. The IgG from patients with pSS has two effects on the submandibular gland. On the one hand, it may act as an inducer of the proinflammatory molecule (PGE<jats:sub>2<\/jats:sub>) that, in turn, inhibits Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase activity. On the other hand, it plays a role in the pathogenesis of dry mouth, abolishing the Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase inhibition and the net K<jats:sup>+<\/jats:sup> efflux stimulation of the salivary gland in response to the authentic agonist pilocarpine, decreasing salivary fluid production.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2010.00716.x","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T09:57:50Z","timestamp":1268301470000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cholinergic autoantibodies from primary Sj\u00f6gren\u2019s syndrome modulate submandibular gland Na<sup>+<\/sup>\/K<sup>+<\/sup>\u2010ATPase activity via prostaglandin E<sub>2<\/sub> and cyclic AMP"],"prefix":"10.1111","volume":"118","author":[{"given":"Daniela","family":"Passafaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Reina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Sterin\u2010Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enri","family":"Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1954.178.1.155"},{"key":"e_1_2_6_3_2","first-page":"424","volume-title":"The alkali metal ions in biology","author":"Thaysen JH","year":"1960"},{"key":"e_1_2_6_4_2","first-page":"773","volume-title":"Physiology of the gastrointestinal tract","author":"Young 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