{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:09:04Z","timestamp":1781658544821,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,9,10]],"date-time":"2010-09-10T00:00:00Z","timestamp":1284076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p> <jats:italic>Drescher J, Schlafer S, Schaudinn C, Riep B, Neumann K, Friedmann A, Petrich A, G\u00f6bel UB, Moter A. Molecular epidemiology and spatial distribution of<\/jats:italic> Selenomonas <jats:italic>spp. in subgingival biofilms.\u2028Eur J Oral Sci 2010; 118: 466\u2013474. \u00a9 2010 Eur J Oral Sci<\/jats:italic><\/jats:p><jats:p>The aetiology of periodontal disease has been a field of intensive research in the past decades. Along with a variety of other putative pathogens, different members of the genus <jats:italic>Selenomonas<\/jats:italic> have repeatedly been associated with both generalized aggressive periodontitis and chronic periodontitis. For the present study, a specific oligonucleotide probe targeting the majority of all oral <jats:italic>Selenomonas<\/jats:italic> spp. was designed. Their prevalence was determined, using dot\u2010blot hybridization, in a total of 742 subgingival samples collected from patients with generalized aggressive (<jats:italic>n<\/jats:italic>\u2003=\u200362) and chronic periodontitis (<jats:italic>n<\/jats:italic>\u2003=\u200382), and from periodontitis\u2010resistant subjects (<jats:italic>n<\/jats:italic>\u2003=\u200319). In addition, fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) and electron microscopy were performed to analyze the spatial arrangement of <jats:italic>Selenomonas<\/jats:italic> in subgingival biofilms collected from patients with generalized aggressive periodontitis. In the samples from patients, <jats:italic>Selenomonas<\/jats:italic> spp. showed a lower prevalence in both diseased groups compared with other putative pathogens, and a relatively high prevalence in the periodontitis\u2010resistant group. Consequently, <jats:italic>Selenomonas<\/jats:italic> spp. do not seem to be suitable diagnostic marker organisms for periodontal disease. By contrast, FISH and electron microscopic analysis of periodontal carriers revealed that <jats:italic>Selenomonas<\/jats:italic> spp. appeared in large numbers in all parts of the collected biofilms and seemed, if present in a site from patients, to make a relevant contribution to their structural organization.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2010.00765.x","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T23:29:35Z","timestamp":1284506975000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Molecular epidemiology and spatial distribution of <i>Selenomonas<\/i> spp. in subgingival 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