{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:29:14Z","timestamp":1777537754248,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:00:00Z","timestamp":1295395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p> <jats:italic>Planello AC, Campos MIG, Meloto CB, Secolin R, Rizatti\u2010Barbosa CM, Line SRP, de Souza AP. Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration.<\/jats:italic>\n          \u2028\n          <jats:italic>Eur J Oral Sci 2011; 119: 1\u20136. \u00a9 2011 Eur J Oral Sci<\/jats:italic> <\/jats:p><jats:p>Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the <jats:italic>MMP1<\/jats:italic> 1G\/2G polymorphism (rs1799750), the <jats:italic>MMP3<\/jats:italic> 5A\/6A polymorphism (rs3025058), and the <jats:italic>MMP9<\/jats:italic> C\/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the <jats:italic>MMP1<\/jats:italic> 2G\/2G genotype and degeneration; in contrast, there was no association between either the <jats:italic>MMP3<\/jats:italic> or the <jats:italic>MMP9<\/jats:italic> genotype and degeneration. Our results may indicate a role for the <jats:italic>MMP1<\/jats:italic> polymorphism in TMJ degeneration.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2010.00803.x","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T11:33:52Z","timestamp":1295436832000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration"],"prefix":"10.1111","volume":"119","author":[{"given":"Aline C.","family":"Planello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I. 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