{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:38:41Z","timestamp":1760708321855},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1519,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1111\/j.1600-0722.2011.00832.x","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T10:35:33Z","timestamp":1309862133000},"page":"275-281","source":"Crossref","is-referenced-by-count":14,"title":["Clozapine-induced salivation: interaction with N-desmethylclozapine and amisulpride in an experimental rat model"],"prefix":"10.1111","volume":"119","author":[{"given":"Tania","family":"Godoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rgen","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB1|cit1","doi-asserted-by":"crossref","DOI":"10.1201\/b14455","volume-title":"The Maudsley 2005-2006 prescribing guide-lines","author":"Taylor","year":"2005"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00213-005-0248-4","article-title":"Clozapine-induced sialorrhea: pathophysiology and management strategies","volume":"185","author":"Praharaj","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/070674370705200607","article-title":"Clozapine-induced hypersalivation: a review of treatment strategies","volume":"52","author":"Sockalingam","year":"2007","journal-title":"Can J Psych"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB4|cit4","article-title":"Amisulpride versus moclobemide in treatment of clozapine-induced hypersalivation","author":"Kreinin","journal-title":"World J Biol Psychiatry"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/0006-3223(95)00296-0","article-title":"Salivary flow-rate and composition in schizophrenic patients on clozapine: subjective reports and laboratory data","volume":"39","author":"Ben-Aryeh","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/S0006-3223(96)89255-9","article-title":"The effect of clozapine on saliva flow rate: a pilot study","volume":"40","author":"Rabinowitz","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/WNF.0b013e3181e204e0","article-title":"Salivary flow rate in patients with schizophrenia on clozapine","volume":"33","author":"Praharaj","year":"2010","journal-title":"Clin Neuropharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00004714-199408000-00012","article-title":"Oesophageal dysfunction in two patients after clozapine treatment (Letter)","volume":"14","author":"McCarthy","year":"1994","journal-title":"J Clin Psychopharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00004714-199408000-00013","article-title":"Clozapine, nocturnal sialorrhea, and choking (Letter)","volume":"14","author":"Pearlman","year":"1994","journal-title":"J Clin Psychopharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2125.1997.t01-1-00605.x","article-title":"The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine","volume":"44","author":"Eierman","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pharmthera.2007.05.004","article-title":"Pharmacology of N-desmethylclozapine","volume":"115","author":"Lameh","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0022034509356055","article-title":"Clozapine: agonistic and antagonistic salivary secretory actions","volume":"89","author":"Ekstr\u00f6m","year":"2010","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0722.2009.00696.x","article-title":"N-desmethylclozapine exerts dual and opposite effects on salivary secretion in the rat","volume":"118","author":"Ekstr\u00f6m","year":"2010","journal-title":"Eur Oral Sci"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1748-1716.1981.tb06868.x","article-title":"Preponderance for either alpha- or beta-adrenoceptor mediated sensitization in the rat submaxillary gland","volume":"113","author":"Ekstr\u00f6m","year":"1981","journal-title":"Acta Physiol Scand"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000061124","volume-title":"Neural mechanisms of salivary glands","author":"Ekstr\u00f6m","year":"1999"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02144740","article-title":"Action of transmitters on the responsiveness of effector cells","volume":"21","author":"Emmelin","year":"1965","journal-title":"Experientia"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/rheumatology\/kep313","article-title":"Inducible nitric oxide synthase increases secretion from inflamed salivary glands","volume":"49","author":"Correia","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1749-6632.2000.tb05391.x","article-title":"Control of salivary secretion by nitric oxide and its role in neuroimmunomodulation","volume":"917","author":"Rettori","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.archoralbio.2010.05.006","article-title":"Participation of the endocannabinoid system in lipopolysaccharide-induced inhibition of salivary secretion","volume":"55","author":"Fernandez-Solari","year":"2010","journal-title":"Arch Oral Biol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000061115","volume-title":"Neural mechanisms of salivary glands","author":"Garrett","year":"1999"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1748-1716.1980.tb06531.x","article-title":"Sensitization of the rat parotid gland to secretagogues following either parasympathetic denervation or sympathetic denervation or decentralization","volume":"108","author":"Ekstr\u00f6m","year":"1980","journal-title":"Acta Physiol Scand"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB22|cit22","first-page":"155","volume-title":"Secretory mechanisms of salivary glands","author":"Schneyer","year":"1967"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1601-0825.2010.01672.x","article-title":"Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland","volume":"16","author":"Cevik-Aras","year":"2010","journal-title":"Oral Dis"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB24|cit24","first-page":"3","article-title":"Muscarinic receptor subtypes in the alimentary tract","volume":"60","author":"Tobin","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.archoralbio.2007.07.012","article-title":"Expression of muscarinic receptor subtypes in salivary glands of rats, sheep and man","volume":"53","author":"Ryberg","year":"2008","journal-title":"Arch Oral Biol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/00912709922008245","article-title":"Clozapine and metabolite concentrations during treatment of patients with chronic schizophrenia","volume":"39","author":"Guitton","year":"1999","journal-title":"J Clin Pharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s002130050028","article-title":"Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics","volume":"148","author":"Spina","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/YIC.0b013e3283277627","article-title":"Determination of pharmacokinetic properties of clozapine and norclozapine in Korean schizophrenia patients","volume":"24","author":"Lee","year":"2009","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2125.1998.00822.x","article-title":"Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance","volume":"46","author":"Schaber","year":"1988","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/BF00172957","article-title":"Determination of clozapine and its N-demethylated metabolite in plasma by use of gas chromatography-mass spectrometry with single ion detection","volume":"95","author":"Bondesson","year":"1988","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/clinchem\/39.8.1656","article-title":"Determination of clozapine, norclozapine, and clozapine-N-oxide in serum by liquid chromatography","volume":"39","author":"Volpicelli","year":"1993","journal-title":"Clin Chem"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/npp.1993.50","article-title":"Tissue concentrations of clozapine and its metabolites in the rat","volume":"9","author":"Baldessarini","year":"1993","journal-title":"Neuropsychopharmacology"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB33|cit33","first-page":"61","article-title":"Sulpiride addition for the treatment of clozapine-induced hypersalivation: preliminary study","volume":"42","author":"Kreinin","year":"2005","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/01.yic.0000188216.92408.69","article-title":"Amisulpride treatment of clozapine-induced hypersalivation in schizophrenia patients: a randomized, double-blind, placebo-controlled cross-over study","volume":"21","author":"Kreinin","year":"2006","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WNF.0b013e31818f1111","article-title":"Moclobemide treatment of clozapine-induced hypersalivation: pilot open study","volume":"32","author":"Kreinin","year":"2009","journal-title":"Clin Neuropharmacol"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00213-009-1521-8","article-title":"Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo","volume":"205","author":"Abbas","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1600-0722.2011.00832.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1097\/MJT.0b013e3181c84bbd","article-title":"Amisulpride improved debilitating clozapine-induced sialorrhea","volume":"18","author":"Praharaj","year":"2011","journal-title":"Am J Ther"}],"container-title":["European Journal of Oral Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0722.2011.00832.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0722.2011.00832.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T11:23:47Z","timestamp":1625657027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0722.2011.00832.x"}},"subtitle":["Clozapine-induced sialorrhoea"],"short-title":[],"issued":{"date-parts":[[2011,7,5]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0722.2011.00832.x","relation":{},"ISSN":["0909-8836"],"issn-type":[{"value":"0909-8836","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,5]]}}}