{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:39:11Z","timestamp":1773319151533,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:italic>Mostowska A, Hozyasz KK, Biedziak B, Wojcicka P, Lianeri M, Jagodzinski PP. Genotype and haplotype analysis of<\/jats:italic> WNT <jats:italic>genes in non\u2010syndromic cleft lip with or without cleft palate.<\/jats:italic>\u2028<jats:italic>Eur J Oral Sci 2012; 120: 1\u20138. \u00a9 2012 Eur J Oral Sci<\/jats:italic><\/jats:p><jats:p>The wingless\u2010type MMTV integration site family (Wnt) signalling pathway plays a crucial role in craniofacial development. Recently, nucleotide variants in <jats:italic>WNT<\/jats:italic> genes have been shown to be associated with oral congenital anomalies, including facial clefts. Therefore, in the current study we decided to assay the association of nucleotide variants in selected <jats:italic>WNT<\/jats:italic> genes with the risk of non\u2010syndromic cleft lip with or without cleft palate (NCL\/P) in the Polish population. Fourteen polymorphisms in <jats:italic>WNT3<\/jats:italic>, <jats:italic>WNT3A<\/jats:italic>, <jats:italic>WNT5A<\/jats:italic>, <jats:italic>WNT8A<\/jats:italic>, <jats:italic>WNT9B<\/jats:italic>, and <jats:italic>WNT11<\/jats:italic> were tested in a group of 210 patients with NCL\/P and in a properly matched control group. The most significant results were found for the <jats:italic>WNT3<\/jats:italic> rs3809857 variant, which, under the assumption of a recessive model, was associated with a two\u2010fold decrease in the risk of NCL\/P (OR<jats:sub>TT vs. GT\u2003+\u2003GG\u2003<\/jats:sub>=\u20030.492, 95% CI: 0.276\u20130.879, <jats:italic>P<\/jats:italic><jats:sub>\u2003<\/jats:sub>=\u20030.015). Moreover, haplotype analysis revealed that <jats:italic>WNT3<\/jats:italic> is significantly correlated with NCL\/P. The global <jats:italic>P<\/jats:italic>\u2010values for haplotypes of rs12452064_rs7207916 and rs3809857_rs12452064_rs7207916 were 0.0034 and 0.0014, respectively, and these results were statistically significant, even after the permutation test correction. In conclusion, our study confirmed the involvement of polymorphisms in the <jats:italic>WNT3<\/jats:italic> gene in NCL\/P aetiology in the tested population.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2011.00938.x","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T20:42:19Z","timestamp":1327956139000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genotype and haplotype analysis of <i>WNT<\/i> genes in non\u2010syndromic cleft lip with or without cleft palate"],"prefix":"10.1111","volume":"120","author":[{"given":"Adrianna","family":"Mostowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil 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