{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:43:35Z","timestamp":1777495415443,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T00:00:00Z","timestamp":1345248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Hypodontia is one of the most common anomalies of human dentition. Recent genetic studies provide information on a number of genes related to both syndromic and non\u2010syndromic forms of hypodontia. Fifty putative single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in 20 genes that play important roles in tooth development were selected, and a case\u2013control study was conducted in 273 subjects with hypodontia (cases) and 200 subjects without hypodontia (controls). <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from samples of whole blood or saliva. Genotyping was performed by matrix\u2010assisted laser desorption ionization time\u2010of\u2010flight mass spectrometry (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). A significant difference was observed, between subjects with non\u2010syndromic hypodontia and controls, in the allele and genotype frequencies of two markers [rs929387 of <jats:styled-content style=\"fixed-case\">GLI<\/jats:styled-content> family zinc finger 3 (<jats:italic><jats:styled-content style=\"fixed-case\">GLI<\/jats:styled-content>3<\/jats:italic>) and rs11001553 of Dickkopf\u2010related protein 1 (<jats:italic><jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>1<\/jats:italic>)]. Similar results were observed in a subgroup analysis of test subjects (stratified by gender or missing tooth position). However, this analysis showed no significant difference in the haplotype distribution between the controls and the affected subjects. These data demonstrate an association between some <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in tooth development\u2010associated genes and sporadic non\u2010syndromic hypodontia in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>an individuals. This information may provide further understanding of the molecular mechanisms of tooth agenesis. Furthermore, these genes can be regarded as candidates for mutation detection in individuals with tooth agenesis.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2012.00986.x","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T09:11:14Z","timestamp":1345281074000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A case\u2013control study of the association between tooth\u2010development gene polymorphisms and non\u2010syndromic hypodontia in the <scp>C<\/scp>hinese <scp>H<\/scp>an population"],"prefix":"10.1111","volume":"120","author":[{"given":"Haochen","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics 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