{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:35:32Z","timestamp":1762374932665},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T00:00:00Z","timestamp":1078963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>The role of agouti signaling protein (ASIP) in human pigmentation pathways is not definitively understood although its murine homologue regulates, in part, pheomelanogenesis. We have reported an association of a polymorphism in the 3\u2032\u2010untranslated region of <jats:italic>ASIP<\/jats:italic> (g.8818A&gt;G) with dark hair and eye color among a group of European\u2010Americans (Am J Hum Genet 2002 March;70:770). Among 147 healthy control subjects, the frequency of the G\u2010allele was 0.12. We hypothesized that this polymorphism would occur at different frequencies among different population groups. Using PCR\u2010RFLP, we genotyped 25 East Asian, 86 African\u2010American, and 207 West African individuals for the <jats:italic>ASIP<\/jats:italic> g.8818A&gt;G polymorphism. The g.8818G\u2010allele was present in the West African sample at a frequency of 0.80, in the African\u2010American sample at a frequency of 0.62, and in the East Asian sample at 0.28. The difference in allele frequency among population groups was statistically significant (P\u2003&lt;\u20030.0001). Although the effect of the g.8818A&gt;G polymorphism upon ASIP function is unknown, the large difference in allele frequency between our West African and European\u2010American sample populations lends support to the notion that this gene may be important in human pigmentation.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2004.00134.x","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T07:36:52Z","timestamp":1104219412000},"page":"185-187","source":"Crossref","is-referenced-by-count":23,"title":["Population Differences in the Frequency of the Agouti Signaling Protein g.8818A&gt;G Polymorphism"],"prefix":"10.1111","volume":"17","author":[{"given":"Charnita","family":"Zeigler\u2010Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saarene","family":"Panossian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serigne M.","family":"Gueye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Jalloh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ofori\u2010Adjei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Kanetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/371799a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12292572"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.3.9898"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.9760"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.2.223"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/339076"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140406.x"},{"issue":"4","key":"e_1_2_7_9_2","first-page":"283","article-title":"Glutathione S\u2010transferase\u2010mu (GSTM1) and \u2010theta (GSTT1) genotypes in the etiology of prostate cancer","volume":"8","author":"Rebbeck TR","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066695"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1289\/ehp.99107517","article-title":"Collection of genomic DNA by buccal swabs for polymerase chain reaction\u2010based biomarker assays","volume":"107","author":"Walker AH","year":"1999","journal-title":"Environ Health Perspect"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90112-0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101626200"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00007.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00062.x"}],"container-title":["Pigment Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0749.2004.00134.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0749.2004.00134.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T19:04:12Z","timestamp":1695841452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0749.2004.00134.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,11]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1111\/j.1600-0749.2004.00134.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0749.2004.00134.x","archive":["Portico"],"relation":{},"ISSN":["0893-5785","1600-0749"],"issn-type":[{"value":"0893-5785","type":"print"},{"value":"1600-0749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,11]]}}}