{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:31:09Z","timestamp":1793935869908,"version":"4.8.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T00:00:00Z","timestamp":1084233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. Pollution plays a major role in the production of free radicals. Gujarat, a highly industrialized state in India has a high prevalence of vitiligo patients. No previous studies were done on the age\u2010dependent antioxidant status of vitiligo patients in Baroda city, Gujarat. Blood samples were collected from vitiligo patients of different age groups (5\u201315, 16\u201325, 26\u201335, 36\u201345\u2003yr) and from age matched healthy volunteers. Antioxidant enzymes in blood such as catalase, superoxide dismutase, glutathione peroxidase and non\u2010enzymatic antioxidants such as reduced glutathione and plasma vitamin E were estimated. Lipid peroxidation levels in erythrocytes and the reducing equivalent system, i.e. glucose\u20106\u2010phosphate dehydrogenase were also measured. Significant increase in superoxide dismutase activity and lipid peroxidation levels in erythrocytes was observed in all age groups of vitiligo patients as compared with age\u2010matched healthy controls, wherein an increase of 55% (P\u2003&lt;\u20030.02) was observed in superoxide dismutase activity and lipid peroxidation levels in 36\u201345\u2003yr age group. Whole blood glutathione levels, erythrocyte glutathione peroxidase and glucose\u20106\u2010phosphate dehydrogenase activity were decreased significantly, whereas erythrocyte catalase activity and plasma vitamin E levels were not different in vitiligo patients as compared with age\u2010matched healthy controls. No specific age group showed a significant difference. This is the first report on the age\u2010dependent antioxidant status of vitiligo patients in Baroda. The disease affects individuals of any age group as shown in this study and systemic oxidative stress might precipitate the pathogenesis of vitiligo in susceptible patients.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2004.00149.x","type":"journal-article","created":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T08:51:22Z","timestamp":1084265482000},"page":"289-294","source":"Crossref","is-referenced-by-count":67,"title":["Study on the Antioxidant Status of Vitiligo Patients of Different Age Groups in Baroda"],"prefix":"10.1111","volume":"17","author":[{"given":"Deepali","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Shajil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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