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The protein product of the <jats:italic>OA1<\/jats:italic> gene is a pigment cell specific membrane glycoprotein, displaying structural and functional features of G protein\u2010coupled receptors (GPCRs). However, in contrast to all other previously characterized GPCRs, OA1 is not localized to the plasma membrane, but is targeted to intracellular organelles, namely late endosomes\/lysosomes and melanosomes. These unique characteristics suggest that OA1 represents the first example described so far of an exclusively intracellular GPCR and regulates melanosome biogenesis by transducing signals from the organelle lumen to the cytosol. These findings support previous hypotheses that GPCR\u2010mediated signaling might also operate at the internal membranes in mammalian cells.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2005.00240.x","type":"journal-article","created":{"date-parts":[[2005,7,19]],"date-time":"2005-07-19T20:25:17Z","timestamp":1121804717000},"page":"227-233","source":"Crossref","is-referenced-by-count":59,"title":["The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis"],"prefix":"10.1111","volume":"18","author":[{"given":"M. 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