{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:56:00Z","timestamp":1770148560597,"version":"3.49.0"},"reference-count":99,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,7,19]],"date-time":"2005-07-19T00:00:00Z","timestamp":1121731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune\u2010mediated loss of epidermal melanocytes. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self\u2010antigens shared by normal melanocytes and melanoma cells are found in both conditions and might prove important in melanocyte destruction, yet the resulting immune reactions are completely different. From this standpoint, the selective destruction of pigment cells that occurs in cases of vitiligo is the therapeutic goal sought in melanoma research. In the present article, we will address these issues by reviewing current literature on the subject as well as by posing some speculations.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2005.00244.x","type":"journal-article","created":{"date-parts":[[2005,7,19]],"date-time":"2005-07-19T20:25:17Z","timestamp":1121804717000},"page":"234-242","source":"Crossref","is-referenced-by-count":37,"title":["Melanocyte\u2010specific, cytotoxic T cell responses in vitiligo: the effective variant of melanoma immunity?"],"prefix":"10.1111","volume":"18","author":[{"given":"Silvia","family":"Garbelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Giachino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,19]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1994.tb00013.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5284.94"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35021081"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.4.989"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.5.651"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700209"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.3.1005"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00805.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80049-0"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.002005"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1953.01540030079011"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.701"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00126-0"},{"key":"e_1_2_3_15_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archderm.1987.01660320095019","article-title":"Prognostic significance of hypopigmentation in malignant melanoma","volume":"123","author":"Bystryn J.C.","year":"1987","journal-title":"Arch. Dermatol."},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199804)28:04<1143::AID-IMMU1143>3.0.CO;2-K"},{"key":"e_1_2_3_17_1","first-page":"748","article-title":"Characterization of the functional specificity of a cloned T\u2010cell receptor heterodimer recognizing the MART\u20101 melanoma antigen","volume":"55","author":"Cole D.J.","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.35"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981209)78:6<699::AID-IJC6>3.0.CO;2-U"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(00)01844-5"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/334395a0"},{"key":"e_1_2_3_22_1","first-page":"2047","article-title":"Melanoma patients respond to a cytotoxic T lymphocyte\u2010defined self\u2010peptide with diverse and nonoverlapping T\u2010cell receptor repertoires","volume":"61","author":"Dietrich P.Y.","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.5103"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80546-4"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6644"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80033-6"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5354.1166"},{"key":"e_1_2_3_28_1","first-page":"277","article-title":"Mononuclear cell subpopulations and infiltrating lymphocytes in erythema dyschromicum perstans and vitiligo","volume":"2","author":"Gross A.","year":"1987","journal-title":"Histol. Histopathol."},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5291.1363"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2 <735::AID-CNCR2820751418>3.0.CO;2-Q"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.3.812"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000515)86:4<538::AID-IJC16>3.0.CO;2-G"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02786397"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6458"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.347"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199807000-00001"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102-999"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01363.x"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01605.x"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.12.7284"},{"key":"e_1_2_3_41_1","first-page":"1219","article-title":"Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance","volume":"148","author":"Le Poole I.C.","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2004.00825.x"},{"key":"e_1_2_3_43_1","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.4049\/jimmunol.163.11.6292","article-title":"Increased vaccine\u2010specific T cell frequency after peptide\u2010based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression","volume":"163","author":"Lee K.H.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/9525"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2828"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050501"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.647"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118958"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12413.x"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6253"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12368.x"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00116-9"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7535476"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200004)190:5<572::AID-PATH570>3.0.CO;2-9"},{"key":"e_1_2_3_55_1","first-page":"158","article-title":"Vitiligo with raised borders. Report of two cases","volume":"48","author":"Michaelsson G.","year":"1968","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_3_56_1","first-page":"2535","article-title":"Lack of terminally differentiated tumor\u2010specific CD8+ T cells at tumor site in spite of antitumor immunity to self\u2010antigens in human metastatic melanoma","volume":"63","author":"Mortarini R.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00006"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70182-9"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00651.x"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1203"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1163"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01408.x"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200102)31:2<412::AID-IMMU412>3.0.CO;2-4"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18814.x"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.495"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.50.86"},{"key":"e_1_2_3_68_1","first-page":"1053","article-title":"A unique phenotype of skin\u2010associated lymphocytes in humans. Preferential expression of the HECA\u2010452 epitope by benign and malignant T cells at cutaneous sites","volume":"136","author":"Picker L.J.","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.5.705"},{"key":"e_1_2_3_70_1","first-page":"796s","article-title":"Expansion and functional maturation of human tumor antigen\u2010specific CD8+ T cells after vaccination with antigenic peptide","volume":"7","author":"Pittet M.J.","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206462"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9781"},{"key":"e_1_2_3_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1913"},{"key":"e_1_2_3_74_1","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.4049\/jimmunol.154.5.2257","article-title":"Induction of tumor\u2010reactive CTL from peripheral blood and tumor\u2010infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART\u20101","volume":"154","author":"Rivoltini L.","year":"1995","journal-title":"J. Immunol."},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.3.1220"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18809.x"},{"key":"e_1_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(96)80078-1"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.9.1641"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18808.x"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)84664-6"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.15.1159"},{"key":"e_1_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80048-5"},{"key":"e_1_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247240"},{"key":"e_1_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200003000-00012"},{"key":"e_1_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.4.1231"},{"key":"e_1_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.2.527"},{"key":"e_1_2_3_87_1","first-page":"256","article-title":"Melanoma antigens recognised by CD8+ and CD4+ T cells","volume":"10","author":"Storkus W.J.","year":"2000","journal-title":"Forum (Genova)."},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12460906"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1669"},{"key":"e_1_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.4.1750"},{"key":"e_1_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.1.533"},{"key":"e_1_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80050-7"},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.4.1375"},{"key":"e_1_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00038.x"},{"key":"e_1_2_3_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000069521.42488.1B"},{"key":"e_1_2_3_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780138"},{"key":"e_1_2_3_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780318"},{"key":"e_1_2_3_98_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1637"},{"key":"e_1_2_3_99_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20010809"},{"key":"e_1_2_3_100_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011658"}],"container-title":["Pigment Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0749.2005.00244.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0749.2005.00244.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:10:51Z","timestamp":1697267451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0749.2005.00244.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,19]]},"references-count":99,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1600-0749.2005.00244.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0749.2005.00244.x","archive":["Portico"],"relation":{},"ISSN":["0893-5785","1600-0749"],"issn-type":[{"value":"0893-5785","type":"print"},{"value":"1600-0749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,19]]}}}