{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:37:48Z","timestamp":1768487868095,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,7,25]],"date-time":"2005-07-25T00:00:00Z","timestamp":1122249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We have previously identified three naturally occurring mutations in the medaka fish tyrosinase gene caused by transposable element insertions. <jats:italic>Tyr<\/jats:italic>\u2010<jats:italic>i<\/jats:italic><jats:sup>b<\/jats:sup> is one of these, containing the <jats:italic>Tol2<\/jats:italic> element in the promoter region. Its homozygous carriers exhibit a weak oculocutaneous albino phenotype. We report here spontaneous reversion of the albino phenotype to the wild\u2010type pigmentation, associated with excision of the <jats:italic>Tol2<\/jats:italic> element. The newly arising mutant gene is inherited in the Mendelian fashion. Thus, oculocutaneous albinism is not strictly irreversible, at least in this organism and the results also indicate that the insertion of the <jats:italic>Tol2<\/jats:italic> element is the main, and possibly the only, cause of the <jats:italic>i<\/jats:italic><jats:sup>b<\/jats:sup> albinism. Importantly our data also suggest that medaka fish possess an active transposase.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2005.00247.x","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T12:34:08Z","timestamp":1126701248000},"page":"382-384","source":"Crossref","is-referenced-by-count":15,"title":["Reversion mutation of <i>i<\/i><sup>b<\/sup> oculocutaneous albinism to wild\u2010type pigmentation in medaka fish"],"prefix":"10.1111","volume":"18","author":[{"given":"Atsuo","family":"Iida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Wakamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Shima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,25]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0749.2003.00122.x"},{"key":"e_1_2_3_3_1","volume-title":"The Integrated Book for the Biology of the Medaka","author":"Iwamatsu T.","year":"1997"},{"key":"e_1_2_3_4_1","first-page":"183","article-title":"Mechanisms of hypopigmentation in human oculocutaneous albinism","volume":"256","author":"King R.A.","year":"1988","journal-title":"Prog. 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