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The protein MIA, which is strongly expressed in melanoma cells but not in melanocytes, is likely to represent a key molecule regulating melanoma progression. Consistent with this, several in vitro and in vivo model systems indicate a direct involvement of MIA in melanoma migration and invasion, with recent studies suggesting a central role for MIA in early melanoma development by regulating important melanoma\u2010related pathways and molecules. The latest developments in MIA research are summarized in this review, which describes recently published data related to the MIA protein structure and function, the role of MIA in melanoma development and progression, and the regulation of MIA expression. Furthermore, newly discovered MIA\u2010homologous genes are discussed.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2005.00274.x","type":"journal-article","created":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T15:23:47Z","timestamp":1129130627000},"page":"411-416","source":"Crossref","is-referenced-by-count":51,"title":["Melanoma inhibitory activity (MIA): an important molecule in melanoma development and progression"],"prefix":"10.1111","volume":"18","author":[{"given":"Anja\u2010Katrin","family":"Bosserhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199212000-00006"},{"key":"e_1_2_10_3_1","first-page":"5695","article-title":"Cloning of a novel malignant melanoma\u2010derived growth\u2010regulatory protein, MIA","volume":"54","author":"Blesch A.","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_10_4_1","first-page":"5358","article-title":"Autocrine tumor cell growth\u2010inhibiting activities from human malignant melanoma","volume":"49","author":"Bogdahn U.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.1.490"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<446::AID-PATH267>3.0.CO;2-Y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200108000-00013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212639200"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000097191.12477.5D"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2003.12.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002876200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206460"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00028.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6159"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1424"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00235.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00501.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01099.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20549"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00050.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109236200"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014961408029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80008-8"},{"key":"e_1_2_10_24_1","first-page":"173","article-title":"Transcription factors involved in development and progression of malignant melanoma","volume":"19","author":"Poser I.","year":"2004","journal-title":"Histol. 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