{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:43:05Z","timestamp":1793659385003,"version":"4.5.1"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Sun exposure is responsible for detrimental damage ranging from sunburn to photoaging and skin cancer. This damage is likely to be influenced by constitutive pigmentation. The relationship between ultraviolet (UV) sensitivity and skin color type was analyzed on 42 ex vivo skin samples objectively classified from light to dark skin, based on their values of individual typology angle (ITA) determined by colorimetric parameters. The biologically efficient dose (BED) was determined for each sample by quantifying sunburn cells after exposure to increasing doses of UV solar\u2010simulated radiation. Typical UV\u2010induced biologic markers, other than erythema, such as DNA damage, apoptosis and p53 accumulation, were analyzed. A statistically significant correlation was found between ITA and BED and, ITA and DNA damage. Interestingly, DNA lesions were distributed throughout the whole epidermal layers and the uppermost dermal cells in light, intermediate and tanned skin while they were restricted to suprabasal epidermal layers in brown or dark skin. Our data support, at the cellular level, the relationship between UV sensitivity and skin color type. They emphasize the impact of DNA damage accumulation in basal layer in relation to the prevalence of skin cancer.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2006.00338.x","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T05:26:33Z","timestamp":1157952393000},"page":"606-614","source":"Crossref","is-referenced-by-count":159,"title":["Relationship between skin response to ultraviolet exposure and skin color type"],"prefix":"10.1111","volume":"19","author":[{"given":"S.","family":"Del Bino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bessac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bernerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2146"},{"key":"e_1_2_6_3_1","first-page":"288","article-title":"The relationship of immediate pigment darkening to minimal erythemal dose, skin type, and eye color","volume":"2","author":"Agin P.P.","year":"1985","journal-title":"Photodermatology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o071.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734203100"},{"key":"e_1_2_6_6_1","first-page":"43","article-title":"Phenotypic characters related to skin type and minimal erythemal dose","volume":"4","author":"Andreassi L.","year":"1987","journal-title":"Photodermatology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110409.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8465"},{"key":"e_1_2_6_9_1","first-page":"242","article-title":"The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV\u2010solar simulated radiation","volume":"13","author":"Bernerd F.","year":"2003","journal-title":"Eur. J. Dermatol."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10124"},{"key":"e_1_2_6_11_1","first-page":"2697","article-title":"Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation","volume":"53","author":"Campbell C.","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1991.tb00561.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00027.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05886.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2004.tb01273.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1 <245::AID-CNCR2820751310>3.0.CO;2-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"e_1_2_6_18_1","first-page":"24","article-title":"Soleil et peau","volume":"2","author":"Fitzpatrick T.B.","year":"1975","journal-title":"J. Med. Esthet."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70103-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00076.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70455-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00085-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2 <667::AID-CNCR2820751409>3.0.CO;2-I"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2004.00104.x"},{"key":"e_1_2_6_25_1","first-page":"257","article-title":"Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma","volume":"72","author":"Holman C.D.","year":"1984","journal-title":"J. Natl Cancer Inst."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00072.x"},{"key":"e_1_2_6_27_1","first-page":"873","volume-title":"Physiology, Biochemistry and Molecular Biology of the Skin","author":"Jimbow K.","year":"1991"},{"key":"e_1_2_6_28_1","first-page":"6304","article-title":"Participation of p53 protein in the cellular response to DNA damage","volume":"51","author":"Kastan M.B.","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1001\/archderm.1996.03890280106015","article-title":"Cutaneous malignant melanoma and sun exposure. Recent developments in epidemiology","volume":"132","author":"Katsambas A.","year":"1996","journal-title":"Arch. Dermatol"},{"key":"e_1_2_6_30_1","first-page":"327","article-title":"UVB\u2010induced erythema, delayed tanning, and UVA\u2010induced immediate tanning in Japanese skin","volume":"3","author":"Kawada A.","year":"1986","journal-title":"Photodermatology"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.561"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1838"},{"key":"e_1_2_6_33_1","first-page":"157","volume-title":"Sunlight and Man","author":"Kligman A.M","year":"1974"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00178.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb11851.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.11"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90184-1"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90293-7"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12325517"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70148-U"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04749.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2005.11.008"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1993.tb01335.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.006"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700287"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00488.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060031011"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2006.00302.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22609.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(99)00025-3"},{"key":"e_1_2_6_51_1","first-page":"87","volume-title":"Brown Melanoderma","author":"Satoh Y.","year":"1986"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70106-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.160103.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000248520"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12265342"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0865fje"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23760.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403994101"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12398276"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120790"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1997.tb00233.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00047.x"},{"key":"e_1_2_6_63_1","first-page":"127","article-title":"The sunburn cell","volume":"4","author":"Young A.R.","year":"1987","journal-title":"Photodermatology"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12491807"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12349031"}],"container-title":["Pigment Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0749.2006.00338.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0749.2006.00338.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:20:04Z","timestamp":1696990804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0749.2006.00338.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,11]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1600-0749.2006.00338.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0749.2006.00338.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1053907.505854","asserted-by":"object"}]},"ISSN":["0893-5785","1600-0749"],"issn-type":[{"value":"0893-5785","type":"print"},{"value":"1600-0749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,11]]}}}