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Of these, perhaps the most promising are multimarker real\u2010time RT\u2010PCR and microarray for detection of circulating CMM cells in peripheral blood. While the optimal set of markers is still to be identified that can accurately assess disease severity and progression at all clinical stages of the disease, recent progress has been dramatic. Here we provide an exhaustive review of recent studies in which a variety of markers are assessed. Moreover, the efficacy of the markers relative to clinical stage is discussed in light of experimental findings. From these studies, it is apparent that researchers are now much closer to defining a set of markers of circulating cells that can be utilized in routine diagnostic tests.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2006.00356.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:57:25Z","timestamp":1166687845000},"page":"80-91","source":"Crossref","is-referenced-by-count":35,"title":["Molecular markers of circulating melanoma cells"],"prefix":"10.1111","volume":"20","author":[{"given":"Sandra","family":"Medic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Heenan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mel","family":"Ziman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.4.1227"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00008390-200004000-00003","article-title":"The detection of tyrosinase mRNA in the peripheral blood of stage i melanoma patients is not of clinical relevance in predicting metastasis risk and survival","volume":"10","author":"Aubin F.","year":"2000","journal-title":"Melanoma Res."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3635"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.4.443"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35020115"},{"key":"e_1_2_5_7_1","first-page":"529","article-title":"Aberrant Pax3 and Pax7 expression. 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