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Glycerophosphoethanolamine (GPEtn) is the major species in the retinal pigment epithelium (RPE); 93% of the GPEtn contain polyunsaturated fatty acids, notably docosahexanoic acid and arachidonic acid, in the <jats:italic>sn<\/jats:italic>\u20102 position. RPE melanosomes also contain detectable quantities of glycerophosphoserine and glycerophosphate; these species were not detected in the uveal samples. While the structural and functional roles of melanosomal lipids largely remain to be determined, these different lipid compositions reported herein offer new insights into the roles of melanosomes in the different ocular tissues.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2006.00357.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:57:25Z","timestamp":1166687845000},"page":"61-69","source":"Crossref","is-referenced-by-count":14,"title":["The differing embryonic origins of retinal and uveal (iris\/ciliary body and choroid) melanosomes are mirrored by their phospholipid composition"],"prefix":"10.1111","volume":"20","author":[{"given":"Weslyn C.","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(76)90198-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr0502323"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr025562r"},{"key":"e_1_2_6_5_1","first-page":"1433","article-title":"Lipids in human lipofuscin\u2010enriched subcellular\u2010fractions of 2 age populations \u2013 comparison with rod outer segments and neural retina","volume":"31","author":"Bazan H.E.P.","year":"1990","journal-title":"Invest. 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