{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:15:36Z","timestamp":1791216936101,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The <jats:italic>microphthalmia<\/jats:italic>\u2010associated transcription factor (MITF) is a member of the MYC family of basic helix\u2013loop\u2013helix leucine zipper transcription factors. The corresponding gene was initially discovered in the mouse based on mutations which affect the development of several different cell types, including melanocytes and retinal pigment epithelium cells. Subsequently, it was shown to be associated with deafness and hypo\u2010pigmentation disorders in humans. More recently, the gene has been shown to be critical in melanoma formation and to play a role in melanocyte stem cell maintenance. Thus, the mouse <jats:italic>Mitf<\/jats:italic> gene represents an important model system for the study of human disease as well as an interesting model for the study of transcription factor function in the organism. Here we use the evolutionary relationship of <jats:italic>Mitf<\/jats:italic> genes from numerous distantly related species, including vertebrates and invertebrates, to identify novel conserved domains in the Mitf protein and regions of possible functional importance in the 3\u2032 untranslated region. We also characterize the nine different 5\u2032 exons of the <jats:italic>Mitf<\/jats:italic> gene and identify a new 5\u2032 exon in the <jats:italic>Drosophila Mitf<\/jats:italic> gene. Our analysis sheds new light on the conservation of the <jats:italic>Mitf<\/jats:italic> gene and protein and opens the door for further functional analysis.<\/jats:p>","DOI":"10.1111\/j.1600-0749.2007.00373.x","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T17:50:32Z","timestamp":1178214632000},"page":"185-200","source":"Crossref","is-referenced-by-count":35,"title":["Evolutionary sequence comparison of the <i>Mitf<\/i> gene reveals novel conserved domains"],"prefix":"10.1111","volume":"20","author":[{"given":"J\u00f3n Hallsteinn","family":"Hallsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikta S.","family":"Haflidad\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schepsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Arnheiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eir\u00edkur","family":"Steingr\u00edmsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8838"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199801000-00003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-59259-994-3_2","volume-title":"From Melanocytes to Malignant Melanoma: The Progression to Malignancy","author":"Arnheiter H.","year":"2006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5172"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.07.031"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.827"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.13.1907"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1091\/mbc.e06-05-0470","article-title":"Microphthalmia\u2010associated transcription factor interactions with 14\u20133\u20103 modulate differentiation of committed myeloid precursors","volume":"17","author":"Bronisz A.","year":"2006","journal-title":"Mol. 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