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A comprehensive literature search on the PubMed database was performed using the keywords \u2018periodontitis\u2019 or \u2018periodontal disease\u2019 in combination with the words \u2018genes\u2019, \u2018mutation\u2019, \u2018SNP\u2019 or \u2018polymorphism\u2019. The studies selected were written in English, had a case\u2013control design, and reported genotype distribution. Only studies with at least 100 individuals in either the case or control group were included. Research on genetic polymorphisms has only had limited success in identifying significant and reproducible genetic factors for susceptibility to aggressive periodontitis and chronic periodontitis. Taking together the data published on gene polymorphisms in aggressive and chronic periodontitis, we conclude that there are differences among the various studies for the rare allele carriage rates. Nevertheless, there is some evidence that polymorphisms in the\n                    <jats:italic>IL1B<\/jats:italic>\n                    ,\n                    <jats:italic>IL1RN<\/jats:italic>\n                    ,\n                    <jats:italic>Fc\u03b3RIIIb<\/jats:italic>\n                    ,\n                    <jats:italic>VDR<\/jats:italic>\n                    and\n                    <jats:italic>TLR4<\/jats:italic>\n                    genes may be associated with aggressive periodontitis susceptibility, and polymorphisms in the\n                    <jats:italic>IL1B<\/jats:italic>\n                    ,\n                    <jats:italic>IL1RN<\/jats:italic>\n                    ,\n                    <jats:italic>IL6<\/jats:italic>\n                    ,\n                    <jats:italic>IL10<\/jats:italic>\n                    ,\n                    <jats:italic>VDR<\/jats:italic>\n                    ,\n                    <jats:italic>CD14<\/jats:italic>\n                    ,\n                    <jats:italic>TLR4<\/jats:italic>\n                    and\n                    <jats:italic>MMP1<\/jats:italic>\n                    genes may be associated with chronic periodontitis susceptibility as a single genetic factor in certain populations. Future studies should apply stricter disease classifications, use larger study cohorts, adjust for relevant risk factors in aggressive and chronic periodontiti,s and include analysis of multiple genes and polymorphisms. Establishing consortia and performing collaborative studies may help to conquer the limitations of small sample size and limited statistical power.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0757.2011.00415.x","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T17:19:53Z","timestamp":1322846393000},"page":"37-68","source":"Crossref","is-referenced-by-count":225,"title":["Genetic susceptibility to periodontitis"],"prefix":"10.1111","volume":"58","author":[{"given":"Marja L.","family":"Laine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Crielaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno 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