{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:31:32Z","timestamp":1760887892505},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":9280,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:p>The T\u2010cell triggered effector systems have been emphasized as the most important agents mediating periodontal disease in recent years. It was therefore tempting to investigate whether T\u2010cell suppression with cyclosporin A (CS\u2010A) had an effect on the establishment and progression of the disease in rats monoassociated with Actinomyces viscosus Ny 1. The experiment was carried out with two treatments (16 rats each) in two isolators. In one of the isolators CS\u2010A was added to the high sucrose diet 2000 aiming at a dosage of 15 mg per day and kg bodyweight. In the second isolator (control) the same diet without CS\u2010A was fed. At day 25, 38, 52 and 65 four animals from each treatment were removed from the isolators. Dental plaque and alveolar bone loss were evaluated. The cellular composition of blood and histological changes of periodontal lesions on a light and electron microscopic level were monitored. In addition antibody titers and the T\u2010cell suppressing effect of individual serum samples of all animals were determined.<\/jats:p><jats:p>Despite clearcut treatment differences in antibody titers as well as an interference by the sera of CS\u2010A treated animals with the Con A dependent lymphocyte activation, bone loss was observed in both groups. Haematological and histological investigation revealed only minor differences between the two treatments. It is concluded that periodontal disease in monoinfected rats seems to be the result of a multitude of pathomechanisms and not to be strictly correlated with T\u2010cell dependent hypersensitivity.<\/jats:p>","DOI":"10.1111\/j.1600-0765.1981.tb00947.x","type":"journal-article","created":{"date-parts":[[2006,7,2]],"date-time":"2006-07-02T01:32:42Z","timestamp":1151803962000},"page":"26-38","source":"Crossref","is-referenced-by-count":18,"title":["The effect of cyclosporin A on periodontal disease in rats monoassociated with Actinomyces viscosus Ny 1"],"prefix":"10.1111","volume":"16","author":[{"given":"B.","family":"Guggenheim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gaegauf\u2010Zollinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hefti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Burckhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1744"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1975.tb01723.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/iai.13.5.1363-1368.1976","article-title":"Importance of Actinomyces and certain gram\u2010negative anaerobic organisms in the transformation of lymphocytes from patients with periodontal disease","volume":"13","author":"Baker J. J.","year":"1976","journal-title":"Infection and Immunity"},{"key":"e_1_2_1_5_1","first-page":"631","article-title":"Comparative study of in vitro and in vivo drug effects on cell\u2010mediated cytotoxicity","volume":"31","author":"Borel J. 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