{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:18:04Z","timestamp":1773011884132,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":4017,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>We re\u2010evaluated several antibiotics including newer ones, for their <jats:italic>in vitro<\/jats:italic> killing activity, as well as their inhibitory activity, against clinical isolates of periodontopathic bacteria. Tetracyclines were active against <jats:italic>Porphyromonas gingivalis<\/jats:italic>, and were highly active against <jats:italic>Prevotella intermedia<\/jats:italic>, but demonstrated only a low killing activity against <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>. Rokitamycin. a new macrolide, and clindamycin were highly active against <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>P. intermedia<\/jats:italic>, but showed very weak killing activity against <jats:italic>A. actinomycetemcomitans<\/jats:italic>. Quinolones demonstrated excellent bactericidal activity against <jats:italic>A. actinomycetemcomitans<\/jats:italic>, and good inhibitory and bactericidal activity against <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>P. intermedia<\/jats:italic>. Metronidazole had an activity almost equivalent to quinolones against <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>P. intermedia<\/jats:italic>; but it was the least active against <jats:italic>A. actinomycetemcomitans<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1600-0765.1995.tb02136.x","type":"journal-article","created":{"date-parts":[[2006,7,2]],"date-time":"2006-07-02T06:38:23Z","timestamp":1151822303000},"page":"290-293","source":"Crossref","is-referenced-by-count":41,"title":["<i>In vitro<\/i> activity of tetracyclines, macrolides, quinolones, clindamycin and metronidazole against periodontopathic bacteria"],"prefix":"10.1111","volume":"30","author":[{"given":"Y.","family":"Miyake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tsuruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Widowati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Suginaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.9.545"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.1992.tb01220.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1988.tb01361.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.16.6.1148-1151.1982"},{"key":"e_1_2_1_6_2","unstructured":"KanazawaY KuramataT.Disk sensitivity testing of anaerobic bacteria. 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