{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:31:37Z","timestamp":1760887897517},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":3255,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>Cyclosporin A (CsA), a widely used immunosuppressive agent, is known to induce gingival overgrowth; 30 mg\/kg\/d of CsA were administrated orally in young and adult male Sprague\u2013Dawley rats. The same number of rats received oil\u2010based vehicle solution. After 4, 9, 14 and 19 wk of CsA or vehicle administration 3 control and 3 experimental rats were anaesthetized and tissues fixed by an intracardiac perfusion of fixative solution. Upper and lower jaws were dissected, demineralized and processed for Epon inclusion. Histological examination revealed the presence of large amounts of new cementum (NC) covering extensive areas of the acellular extrinsic fibre cementum (AEFC) in all the root surfaces. NC was particularly abundant at the cervical third of the roots facing the gingival connective tissue, where it occurred as layers, spurs or in both configurations. NC was characterized by its irregular outline, globular body content and infrequent presence of incremental lines. Histomorphometric evaluation by semi\u2010automatic image analysis indicated that the volume and the external surface of NC spurs were 2.86\u20136.49 and 1.29\u20131.97\u2010fold increased comparative to those of the AEFC covering the same root areas. Electron microscopy revealed that NC was a functional tissue with insertion of collagen fibres perpendicularly to the long axis of the root. It can be concluded that under some experimental conditions formation of abundant amounts of NC can be achieved and that these results must be taken into account for a new approach in the treatment of periodontal disease.<\/jats:p>","DOI":"10.1111\/j.1600-0765.1997.tb00570.x","type":"journal-article","created":{"date-parts":[[2006,7,2]],"date-time":"2006-07-02T07:16:48Z","timestamp":1151824608000},"page":"543-556","source":"Crossref","is-referenced-by-count":8,"title":["New cementum formation induced by cyclosporin A: a histological, ultrastructural and histomorphometric study in the rat"],"prefix":"10.1111","volume":"32","author":[{"given":"Charles M.","family":"Ayanoglou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Lesty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01453.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01592.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01120.x"},{"key":"e_1_2_1_6_2","first-page":"172","volume-title":"Periodontal regeneration","author":"Gottlow J.","year":"1993"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199002000-00023"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)36981-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb02072.x"},{"key":"e_1_2_1_10_2","first-page":"1218","article-title":"Cyclosporin A induces new cementum formation in the rat: a histological morphometric and ultrastructural approach","volume":"75","author":"Ayanoglou CM","year":"1996","journal-title":"J Dent Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb02764.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1988.tb04603.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993967"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345530320030701"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.9.533"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1975.tb00020.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02547221"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.10.495"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318774"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90291-4"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4805474"},{"key":"e_1_2_1_22_2","first-page":"85","article-title":"Gingival enlargement. 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