{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:58:15Z","timestamp":1791295095259,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T00:00:00Z","timestamp":1071705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate whether sub\u2010antimicrobial dose doxycycline (SDD) therapy for 120\u2003d in chronic adult periodontitis patients had significant effects on gingival crevicular fluid (GCF) matrix metalloproteinase\u20108 (MMP\u20108) levels, and on gingival tissue MMP\u20109, tissue inhibitor of matrix metalloproteinases\u20101 (TIMP\u20101) and interleukin\u20106 (IL\u20106) levels.<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Tetracycline can significantly inhibit MMP activity in GCF and in gingival tissue, even in much lower dosage then a traditional antimicrobial dosage used in conventional therapy. Sub\u2010antimicrobial dose doxycycline (SDD) therapy has been shown to reduce periodontal disease activity to control MMP and pro\u2010inflammatory cytokines.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 32 patients with incipient to moderate (probing pocket depth \u2248\u200a4\u20137\u2003mm) chronic adult periodontitis were included in the study. Subjects were randomly assigned to two groups. After scaling and root planning (SRP), the SRP\u2003+\u2003SDD group received SDD, 20\u2003mg bid, whereas the SRP\u2003+\u2003placebo group received placebo, 20\u2003mg bid. In the follow\u2010up, efficacy measures included the change in probing pocket depth (PD), clinical attachment level (CAL), bleeding on probing (BOP) and gingival crevicular fluid MMP\u20108 levels, gingival tissue MMP\u20109, TIMP\u20101 and IL\u20106 levels from baseline to 120\u2003d.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> After 120\u2003d, PD and CAL improved significantly in the SRP\u2003+\u2003SDD group. Initial MMP\u20108 levels for the SRP\u2003+\u2003SDD group and the SRP\u2003+\u2003placebo group were 407.13\u2003\u00b1\u2003114.45\u2003ng\/ml and 378.71\u2003\u00b1\u2003189.39\u2003ng\/ml, respectively, with no statistical difference between the two groups. MMP\u20108 levels for the SRP\u2003+\u2003SDD group and the SRP\u2003+\u2003placebo group were: 235.35\u2003\u00b1\u2003134.58\u2003ng\/ml and 364.04\u2003\u00b1\u2003219.27\u2003ng\/ml at 30\u2003d; 157.50\u2003\u00b1\u200395.95\u2003ng\/ml and 236.60\u2003\u00b1 186.16\u2003ng\/ml at 60\u2003d; 102.70\u2003\u00b1\u200367.64\u2003ng\/ml and 208.56\u2003\u00b1\u2003124.54\u2003ng\/ml at 90\u2003d; and 63.77\u2003\u00b1\u200353.33\u2003ng\/ml and 229.13\u2003\u00b1\u2003168.09\u2003ng\/ml at 120\u2003d, respectively. The amount of decrease in MMP\u20108 levels for the SRP\u2003+\u2003SDD group was statistically significant compared to that for the SRP\u2003+\u2003placebo group, especially apparent at 120\u2003d (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05). TIMP\u20101 levels in both groups increased from the baseline to 120\u2003d with statistical significance (<jats:italic>p<\/jats:italic>\u2010value\u2003&lt;\u20030.05), but there was no significant difference between the two groups. Changes in MMP\u20109 and IL\u20106 levels were not statistically significant.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Adjunctive SDD therapy can improve the clinical parameters and this clinical improvement is reflected by controlled level of MMP\u20108 in chronic adult periodontitis after the therapy.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00696.x","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T08:39:50Z","timestamp":1071736790000},"page":"20-26","source":"Crossref","is-referenced-by-count":86,"title":["Effects of sub\u2010antimicrobial dose doxycycline therapy on crevicular fluid MMP\u20108, and gingival tissue MMP\u20109, TIMP\u20101 and IL\u20106 levels in chronic 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