{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:13:00Z","timestamp":1769598780673,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T00:00:00Z","timestamp":1079913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The purpose of this study was to evaluate the relationship between the clinical changes after non\u2010surgical periodontal therapy and interleukin 1 (IL\u20101) in gingival crevicular fluid (GCF) and gingival tissues from patients with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> The inflammatory responses mediated by IL\u20101 play an important role in periodontal tissue destruction. Although numerous studies have attempted to elucidate the dynamic movement involved in chronic periodontitis, the results have often conflicted. Such discrepancies may have been due to the inability to determine clinical disease activity.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Seven patients with chronic periodontitis were examined. The severity of periodontal inflammation was expressed using clinical parameters before and after a scaling and root planing (SRP) procedure. The amounts and concentrations of IL\u20101\u03b1, IL\u20101\u03b2 and IL\u20101 receptor antagonist in GCF were measured by enzyme\u2010linked immunosorbent assay (ELISA) and IL\u20101 activity index was calculated. A needle biopsy in matching gingival tissues was also performed before and after the SRP procedure. The localization and mRNA expression of IL\u20101\u03b2 were determined using histological methods.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Clinical parameters improved slightly after the SRP procedure. Only the probing pocket depth (PPD) was reduced significantly (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05). However, the amount of IL\u20101\u03b2 in GCF was slightly increased. The localization and mRNA expression of IL\u20101\u03b2 could still be observed after the SRP procedure. Therefore, none of the clinical parameters showed a high sensitivity or specificity for evaluating subgingival inflammation.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These observations suggest that IL\u20101 is effective for evaluating in detail the state of subgingival inflammation.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00722.x","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T15:58:43Z","timestamp":1082476723000},"page":"158-167","source":"Crossref","is-referenced-by-count":41,"title":["Effects of scaling and root planing on the amounts of interleukin\u20101 and interleukin\u20101 receptor antagonist and the mRNA expression of interleukin\u20101\u03b2 in gingival crevicular fluid and gingival 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