{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:31:44Z","timestamp":1780630304248,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T00:00:00Z","timestamp":1085097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Recent findings have begun to provide a basis for a causal link between herpesviruses and aggressive periodontitis. One theory is that herpesviruses cooperate with specific bacteria in the etiopathogenesis of the disease. This study examined whether the presence of herpesviruses [human cytomegalovirus (HCMV), Epstein\u2013Barr virus (EBV) type 1, herpes simplex virus (HSV) type 1 and 2] is associated with the presence of putative pathogenic bacteria (<jats:italic>Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Campylobacter rectus, Actinobacillus actinomycetemcomitans<\/jats:italic>) in aggressive periodontitis lesions.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The study included 18 young adults with advanced periodontitis and 16 periodontally healthy subjects from Ankara, Turkey. Subgingival specimens pooled from two sites in each subject were collected by a periodontal curette. Qualitative polymerase chain reaction methodology was used to identify herpesviruses and bacteria. Chi\u2010square tests were employed to determine statistical associations among herpesviruses, bacteria and periodontal disease.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> HCMV, EBV\u20101 and HSV\u20101 were each detected in 72\u201378% of the aggressive periodontitis patients. HSV\u20102 occurred in 17% of the periodontitis patients. EBV\u20101 was detected in one periodontally healthy subject. The study bacteria occurred in 78\u201383% (<jats:italic>P.\u2003gingivalis, T.\u2003forsythia, C.\u2003rectus<\/jats:italic>) and in 44% (<jats:italic>P.\u2003intermedia, A.\u2003actinomycetemcomitans<\/jats:italic>) of the periodontitis samples, and in 0\u201319% of the samples from healthy periodontal sites. HCMV, EBV\u20101 and HSV\u20101 were positively associated with <jats:italic>P.\u2003gingivalis, P.\u2003intermedia, T.\u2003forsythia<\/jats:italic> and <jats:italic>C.\u2003rectus<\/jats:italic>, but not with <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>. HSV\u20102 was not associated with any test bacteria.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These results support the notion that the clinical outcome of some types of severe periodontal infection depends on the presence of specific herpesviruses and bacterial pathogens. Our findings open the door to testing a variety of hypotheses regarding the deleterious aspects of combined herpesviral\u2010bacterial infections in periodontal sites.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00728.x","type":"journal-article","created":{"date-parts":[[2004,6,20]],"date-time":"2004-06-20T15:22:33Z","timestamp":1087744953000},"page":"207-212","source":"Crossref","is-referenced-by-count":85,"title":["Herpesviral\u2013bacterial interrelationships in aggressive 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