{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:37:46Z","timestamp":1773740266343,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T00:00:00Z","timestamp":1092960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Chronic periodontitis causes a low\u2010grade systemic inflammatory response; its standard treatment, however, induces an acute inflammatory response. The aim of this study was to describe the systemic inflammatory reactions to an intensive periodontal treatment regimen.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fourteen otherwise healthy subjects suffering from severe chronic periodontitis were enrolled in a 1\u2003month pilot single\u2010blind trial. Intensive periodontal treatment, consisting of full\u2010mouth subgingival root debridement delivered within a 6\u2010h period, was performed. Periodontal parameters were recorded before and 1\u2003month after completion of treatment. Blood samples were taken at baseline and 1, 3, 5, 7 and 30\u2003days after treatment. Interleukin\u20101 receptor antagonist (IL\u20101Ra), Interleukin\u20106 (IL\u20106) and C\u2010reactive protein (CRP) serum concentrations were determined by enzyme\u2010linked immunosorbent assay (ELISA). Complete blood counts were also performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> One day after treatment, mild neutrophilia and monocytosis (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05) and lymphopenia (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.01) were accompanied by a sharp increase in inflammatory markers (IL\u20101Ra, IL\u20106, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01). A 10\u2010fold increase in CRP (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.001) was detected on day\u20031 and its kinetics followed a pattern of a classical acute phase response (significantly raised concentrations up to 1\u2003week, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01). At 3\u20137\u2003days after treatment, subjects presented also with a mild tendency towards a normocytic anaemic state (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.01) and a degree of lympho\u2010thrombocytosis (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05). The observed changes were similar to those expected following the well\u2010characterized endotoxin\u2010challenge model of inflammation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Intensive periodontal treatment produced an acute systemic inflammatory response of 1\u2003week duration and might represent an alternative to classic endotoxin\u2010challenge or drug\u2010induced models to study acute inflammation in humans.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00741.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T16:04:55Z","timestamp":1093017895000},"page":"294-299","source":"Crossref","is-referenced-by-count":53,"title":["Periodontal therapy: a novel non\u2010drug\u2010induced experimental model to study human inflammation"],"prefix":"10.1111","volume":"39","author":[{"given":"F.","family":"D'Aiuto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nibali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mohamed\u2010Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vallance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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