{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:25:11Z","timestamp":1760887511975},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T00:00:00Z","timestamp":1092096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To determine the ability of a 10% doxycycline hyclate controlled\u2010release polymer (Atridox\u00ae) to suppress periodontopathic bacteria when placed subgingivally following scaling and root planing (Sc\/Rp).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Eight males and seven females, mean age 48\u2003years, with moderate to advanced periodontitis participated in the study. In each patient, bilateral periodontal pockets probing 6\u20137\u2003mm were randomly assigned to treatment by Sc\/Rp\u2003+\u2003doxycycline polymer or by Sc\/Rp alone. Subgingival placement of doxycycline polymer was carried out according to the manufacturer's instructions. Sc\/Rp was performed with hand instruments for at least 10\u2003min in each study tooth. Subgingival samples were collected by paper\u2010points at baseline, at 2\u2003weeks and at 4\u2003weeks post\u2010treatment. Culture methodology was used to isolate and identify putative periodontal pathogens, including <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Dialister pneumosintes<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, <jats:italic>Prevotella intermedia<\/jats:italic>\/<jats:italic>Prevotella nigrescens<\/jats:italic>, <jats:italic>Campylobacter<\/jats:italic> species, <jats:italic>Eubacterium<\/jats:italic> species, <jats:italic>Fusobacterium<\/jats:italic> species, <jats:italic>Peptostreptococcus micros<\/jats:italic>, <jats:italic>Eikenella corrodens<\/jats:italic>, <jats:italic>Staphylococcus<\/jats:italic> species, enteric gram\u2010negative rods, \u03b2\u2010hemolytic streptococci and yeasts. The microbiologic examination was carried out blindly. Microbiological data were analyzed using a General Linear Model Analysis of Variance for within and between group effects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Sites receiving Sc\/Rp\u2003+\u2003doxycycline polymer and sites receiving Sc\/Rp alone exhibited similar levels of periodontal pathogens at baseline and did not differ significantly in total viable counts and proportional recovery of periodontopathic bacteria post\u2010treatment.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Controlled\u2010release doxycycline placed in moderate to deep periodontal pockets caused no significant additional reduction in the subgingival pathogenic microbiota compared to thorough Sc\/Rp alone. Since controlled\u2010release doxycycline may not significantly suppress several subgingival pathogenic microorganisms and seems to possess no distinct advantage over broad\u2010spectra, safe and inexpensive antiseptics, the rationale for its employment in periodontal therapy remains unclear.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00742.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T16:04:55Z","timestamp":1093017895000},"page":"315-319","source":"Crossref","is-referenced-by-count":9,"title":["Initial antimicrobial effect of controlled\u2010release doxycycline in subgingival sites"],"prefix":"10.1111","volume":"39","author":[{"given":"M. G.","family":"Jorgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Safarian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Daneshmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Keim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Slots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00004.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.2801123.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280103.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0170"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.10.849"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280112.x"},{"key":"e_1_2_5_8_2","first-page":"5","article-title":"[In vitro study of chlorhexidine resistance in subgingival bacteria][Article in French]","volume":"25","author":"Kamagate A","year":"2002","journal-title":"Odontostomatol Trop"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291101.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1082"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280106.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.9.s1.6.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003424.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280104.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s2.2.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/19424396.2002.12223275","article-title":"The ins and outs of periodontal antimicrobial therapy","volume":"30","author":"Jorgensen MG","year":"2002","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290611.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_5_19_2","first-page":"1","article-title":"Microbiological examination of root canals and periapical tissues of human teeth","volume":"74","author":"M\u00f6ller \u00c5JR","year":"1966","journal-title":"Odontol Tidskr"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1986.tb00318.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02016.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.10.1085"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.22"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240111.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00416.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03104.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01003.x"},{"key":"e_1_2_5_29_2","article-title":"Periodontal antimicrobials \u2013 Finding the right solutions","author":"Jorgensen MG","journal-title":"Int Dent J"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00335.x"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2004.00742.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2004.00742.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:14:18Z","timestamp":1697044458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2004.00742.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1111\/j.1600-0765.2004.00742.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2004.00742.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,10]]}}}