{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:43Z","timestamp":1791134323215,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T00:00:00Z","timestamp":1100131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The use of adjunctive minocycline with mechanical debridement in treating periodontitis has been widely studied using different methods. However, the results from these studies are equivocal.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The purpose of this study was to clarify the efficacy of the adjunctive use of subgingival minocycline application plus scaling\/root planing as compared with the results of one episode of scaling\/root planing in the treatment of chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>  Fifteen patients were enrolled in this split\u2010mouth clinical trial. Probing depth, clinical attachment loss, gingival index, and bleeding on probing were evaluated at the baseline before scaling\/root planing and 6, 10, 14, and 18\u2003weeks later according to a single\u2010blind protocol. The amount of interleukin\u20101\u03b2 (interleukin\u20101\u03b2 pg\/site) at each lesion was also simultaneously measured in gingival crevicular fluid in a parallel comparison design. After full\u2010mouth baseline measurements and scaling\/root planing, 78 lesions with a residual mean probing depth of 5\u2003mm at anterior teeth were selected and equally distributed in either right or left sites based on a split\u2010mouth symmetrical design and randomly assigned to one of two treatment groups (with or without minocycline administration, <jats:italic>n<\/jats:italic>\u2003=\u200339 for each group).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  Probing depth significantly decreased from the baseline (week\u20030) to week\u20036 after scaling\/root planing (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05) in both groups, but there was no statistically significant difference between the two groups (<jats:italic>p<\/jats:italic>\u2003&gt;\u20030.05). However, at weeks 10, 14, and 18, the experimental group showed significantly greater improvement in pocket reduction than the control group (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05). Similarly, both groups also showed significant decreases in gingival index scores from weeks 0\u20136 (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05), but gingival index reductions at weeks 10, 14, and 18 were statistically significant in favor of the experimental group (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05). The experimental group had more attachment gain than the control group at weeks 14 and 18 (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.05). Values of interleukin\u20101\u03b2 (pg\/site) at the experimental sites were significantly reduced at weeks 10, 14, and 18, as compared to values at control sites (<jats:italic>p\u2003&lt;<\/jats:italic>\u20030.01). Finally, the incidence of bleeding on probing showed no differences between the two groups for any time interval (<jats:italic>p<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In this 18\u2010week clinical trial, the results suggested that scaling\/root planing with adjunctive subgingival administration of minocycline ointment has a significantly better and prolonged effect compared to scaling\/root planing alone on the reduction of probing depth, clinical attachment loss, gingival index, and interleukin\u20101\u03b2 content, but not on bleeding on probing.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00763.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T01:12:45Z","timestamp":1103677965000},"page":"20-27","source":"Crossref","is-referenced-by-count":29,"title":["Efficacy of subgingivally applied minocycline in the treatment of chronic periodontitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Hsein\u2010Kun","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Ji","family":"Chei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,11]]},"reference":[{"key":"e_1_2_20_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.443"},{"key":"e_1_2_20_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02099.x"},{"key":"e_1_2_20_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02186.x"},{"key":"e_1_2_20_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01734.x"},{"key":"e_1_2_20_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.2.137"},{"key":"e_1_2_20_7_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.8.692"},{"key":"e_1_2_20_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.2.73"},{"key":"e_1_2_20_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01838.x"},{"key":"e_1_2_20_10_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.490"},{"key":"e_1_2_20_11_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.22"},{"key":"e_1_2_20_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02398.x"},{"key":"e_1_2_20_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02399.x"},{"key":"e_1_2_20_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.2.167"},{"key":"e_1_2_20_15_2","first-page":"63","article-title":"Clinical and microbiological study of local minocycline delivery (Periocline) following scaling and root planing in recurrent periodontal pockets","volume":"32","author":"Nakagawa T","year":"1991","journal-title":"Bull Tokyo Dent Coll"},{"key":"e_1_2_20_16_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.7.637"},{"key":"e_1_2_20_17_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.11.1058"},{"key":"e_1_2_20_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00599.x"},{"key":"e_1_2_20_19_2","first-page":"1625","article-title":"Pharmacokinetic principles controlling efficacy of oral therapy","volume":"68","author":"Goodson J","year":"1989","journal-title":"J Dent Res"},{"key":"e_1_2_20_20_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1902\/jop.1994.65.7.685","article-title":"A 6\u2010month multi\u2010center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients; 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