{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:21:06Z","timestamp":1793348466276,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T00:00:00Z","timestamp":1101427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The aim of the present study was to determine whether the presence of chronic periodontitis and subsequent periodontal treatment could influence the serum levels of C\u2010reactive protein (CRP), interleukin\u20106 and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in a Japanese population.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sera were obtained from 24 patients with moderate to advanced periodontitis at the baseline examination and at reassessment after completion of treatment. As a control, sera were also obtained from 21 subjects without periodontitis. High\u2010sensitivity CRP (hs\u2010CRP) was measured using nephelometry with a latex particle\u2010enhanced immunoassay and interleukin\u20106 and TNF\u2010\u03b1 were determined by sensitive enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The levels of hs\u2010CRP and interleukin\u20106 in the sera of this Japanese population seemed to be much lower than those reported in other populations. TNF\u2010\u03b1 on the other hand, demonstrated similar levels between this Japanese and other populations. Periodontal status demonstrated a significant improvement in all patients following treatment. There was a trend toward higher hs\u2010CRP levels in patients at baseline compared with control subjects. Hs\u2010CRP level tended to decrease with improvement of the periodontal condition following treatment and approached that of control subjects, although this decline was not statistically significant. interleukin\u20106 and TNF\u2010\u03b1 levels did not change following periodontal treatment. Furthermore, there was no difference in the serum levels of these inflammatory cytokines between patients either at baseline or at reassessment and control subjects.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In this pilot study, we were unable to show that periodontal disease significantly affects the serum levels of systemic inflammatory markers. However, this does not necessarily mean that periodontitis does not contribute to the total burden of inflammation as there was a tendency for hs\u2010CRP to decrease following successful periodontal treatment. Large\u2010scale studies are clearly needed to determine the impact of periodontal disease on systemic inflammation.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2004.00772.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T01:12:45Z","timestamp":1103677965000},"page":"53-58","source":"Crossref","is-referenced-by-count":125,"title":["Effect of periodontal treatment on the C\u2010reactive protein and proinflammatory cytokine levels in Japanese periodontitis 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