{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:35:48Z","timestamp":1773308148824,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T00:00:00Z","timestamp":1119225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Interleukin\u20101 beta (IL\u20101\u03b2) is a potent inflammatory mediator and an important polymorphism in the <jats:italic>locus<\/jats:italic> +3954 (C\/T) of the human <jats:italic>IL1B<\/jats:italic> gene has been shown to affect the levels of this cytokine. This functional polymorphism has been associated with the establishment of inflammatory diseases, including periodontal disease, in European, Asian and North American populations.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to investigate the association between the <jats:italic>IL1B<\/jats:italic> (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis in a sample of Brazilian individuals.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This study employed a cross\u2010sectional design involving individuals from the State of Minas Gerais in the south\u2010eastern region of Brazil. Genomic DNA was obtained from oral swabs of 129 individuals and amplified using the polymerase chain reaction (PCR) with specific primers flanking the <jats:italic>locus<\/jats:italic> +3954 of <jats:italic>IL1B<\/jats:italic>. PCR products were submitted to restriction endonuclease digestion and analyzed by polyacrylamide gel electrophoresis, to distinguish alleles T and C of the <jats:italic>IL1B<\/jats:italic> gene, allowing for the determination of the genotypes and detection of the polymorphism.<\/jats:p><jats:p><jats:bold>Results and Conclusions:\u2002<\/jats:bold> The chronic periodontitis group displayed a higher percentage of the T allele (28%) when compared to the aggressive periodontitis group (10.7%, \u03c7<jats:sup>2<\/jats:sup>\u2003=\u20035.24, <jats:italic>p<\/jats:italic>\u2003=\u20030.02, OR\u2003=\u20030.31, CI\u2003=\u20030.11\u20130.88) and to control group (8.7%, \u03c7<jats:sup>2<\/jats:sup>\u2003=\u20037.11, <jats:italic>p<\/jats:italic>\u2003=\u20030.007, OR\u2003=\u20030.24, CI\u2003=\u20030.08\u20130.73). Our data suggested that the polymorphism in the <jats:italic>locus<\/jats:italic> +3954 of <jats:italic>IL1B<\/jats:italic> gene could be a risk factor for chronic periodontitis in a sample of Brazilian individuals.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2005.00801.x","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T12:58:41Z","timestamp":1119272321000},"page":"306-311","source":"Crossref","is-referenced-by-count":62,"title":["A functional interleukin\u20101\u03b2 gene polymorphism is associated with chronic periodontitis in a sample of Brazilian individuals"],"prefix":"10.1111","volume":"40","author":[{"given":"Paula R.","family":"Moreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra R.","family":"De S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme 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