{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:04:06Z","timestamp":1787015046809,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T00:00:00Z","timestamp":1121644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:\u2002<\/jats:bold>\n                    High levels of serum anti\u2010\n                    <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>\n                    immunoglobulin G (IgG) correlate with reduced extent and severity of periodontal disease and the present study was undertaken to begin testing the hypothesis that proinflammatory cytokines are important in the induction of optimal anti\u2010\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    IgG responses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Studies with pokeweed mitogen indicate that interleukin\u20101\u03b1 (IL\u20101\u03b1) and IL\u20101\u03b2 are necessary for optimal IgG1 and IgG2 production and that prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) and interferon\u2010\u03b3 (IFN\u2010\u03b3) selectively promote IgG2, which is a major component of the anti\u2010\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    response\n                    <jats:italic>in\u2003vivo<\/jats:italic>\n                    . The pokeweed mitogen results suggest that these proinflammatory cytokines would also be necessary for optimal production of IgG specific for\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    Peripheral blood mononuclear cells from\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    \u2010seropositive subjects with localized aggressive periodontitis were stimulated with\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    in immune complexes capable of binding follicular dendritic cells that participate in the induction of recall responses\n                    <jats:italic>in\u2003vivo<\/jats:italic>\n                    . Cultures were manipulated with anti\u2010IL\u20101\u03b1, anti\u2010IL\u20101\u03b2, anti\u2010IFN\u2010\u03b3, anti\u2010IL\u201012, anti\u2010CD21, indomethacin, and PGE\n                    <jats:sub>2<\/jats:sub>\n                    .\n                    <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>\n                    specific IgG production was monitored by enzyme\u2010linked immunosorbent assay (ELISA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Addition of follicular dendritic cells to peripheral blood mononuclear cells cultures resulted in follicular dendritic cell\u2010lymphocyte clusters and increased anti\u2010\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    IgG responses (3\u201340\u2010fold increases) compared with controls lacking follicular dendritic cells. Anti\u2010IL\u20101\u03b1, anti\u2010IL\u20101\u03b2, anti\u2010IFN\u2010\u03b3, anti\u2010IL\u201012, anti\u2010CD21 and indomethacin suppressed anti\u2010\n                    <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\n                    IgG production by half or more. PGE\n                    <jats:sub>2<\/jats:sub>\n                    restored IgG responses suppressed by indomethacin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    The cytokines IL\u20101\u03b1, IL\u20101\u03b2, IFN\u2010\u03b3, IL\u201012, and PGE\n                    <jats:sub>2<\/jats:sub>\n                    were all necessary for optimal production of human anti\u2010\n                    <jats:italic>A.\u2003actinomycetemcomitans and<\/jats:italic>\n                    the need for proinflammatory cytokines including the T helper 1 (Th1) cytokines is consistent with a response with a significant IgG2 component.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0765.2005.00829.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T10:51:29Z","timestamp":1138013489000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Influence of proinflammatory cytokines on\n                    <i>Actinobacillus actinomycetemcomitans<\/i>\n                    specific IgG responses"],"prefix":"10.1111","volume":"41","author":[{"given":"S.","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fakher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Schenkein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Tew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.1.1"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1128\/iai.64.9.3908-3910.1996","article-title":"Influence of anti\u2010Actinobacillus actinomycetemcomitans Y4 (serotype b) lipopolysaccharide on severity of generalized early\u2010onset periodontitis","volume":"64","author":"Califano JV","year":"1996","journal-title":"Infect Immun"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.5.1806-1812.1992"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.6.2400-2407.1993"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00919266"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.4049\/jimmunol.153.11.4948","article-title":"Regulation of human IgG subclass production by cytokines. IFN\u2010gamma and IL\u20106 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2","volume":"153","author":"Kawano Y","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2004-2009.1996"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.5.1677-1682.1994"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.6.2780-2786.2002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.10.1332"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.3.1563-1568.2000"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb03364.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb00633.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb02062.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.4049\/jimmunol.131.4.1714","article-title":"Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology","volume":"131","author":"Szakal AK","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.000515"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200207)32:7<1883::AID-IMMU1888>3.0.CO;2-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.130.6.1367"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01942-1"},{"key":"e_1_2_6_21_2","first-page":"381","article-title":"The physiology of germinal centers","volume":"16","author":"Tsiagbe VK","year":"1996","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.4049\/jimmunol.161.9.4549","article-title":"Evidence for an important interaction between a complement\u2010derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses","volume":"161","author":"Qin D","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6268"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.4049\/jimmunol.163.12.6442","article-title":"Follicular dendritic cells protect malignant B cells from apoptosis induced by anti\u2010Fas and antineoplastic agents","volume":"163","author":"Schwarz YX","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200101)31:1<176::AID-IMMU176>3.0.CO;2-H"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.8.2331"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(99)00038-1"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.4049\/jimmunol.157.8.3404","article-title":"Follicular dendritic cell (FDC) derived Ag and accessory activity in initiation of memory IgG responses in vitro","volume":"157","author":"Wu J","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.6.2400-2407.1993"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.5.1806-1812.1992"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1990.tb00573.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1997.tb00957.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar77"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/298377a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb00628.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1992.tb00635.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80432-X"},{"key":"e_1_2_6_38_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4049\/jimmunol.140.2.341","article-title":"A novel in vivo follicular dendritic cell\u2010dependent iccosome\u2010mediated mechanism for delivery of antigen to antigen\u2010processing cells","volume":"140","author":"Szakal AK","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_6_39_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4049\/jimmunol.140.2.354","article-title":"In vivo obtained antigen presented by germinal center B cells to T cells in vitro","volume":"140","author":"Kosco MH","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1479"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10832"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790080401"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2005.00829.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2005.00829.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:43:41Z","timestamp":1697035421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2005.00829.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,18]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1600-0765.2005.00829.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2005.00829.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,18]]}}}