{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:41:21Z","timestamp":1788633681880,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The responsiveness of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis has been found to play a significant role for susceptibility and resistance to periodontal disease. In the present study we have investigated the effects of two different treatment strategies, which have been found to down\u2010regulate the HPA axis, on ligature\u2010induced periodontitis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In experiment 1, newborn rats were treated with the synthetic glucocorticoid hormone dexamethasone\u201021\u2010phosphate, which permanently down\u2010regulates HPA axis responsiveness. In experiment 2, adult rats were treated with the novel antidepressant drug tianeptine, which opposes the action of stress. Periodontitis was inflicted upon all rats. Just before decapitation the animals received gram\u2010negative bacterial lipopolysaccharide (LPS) to induce a robust immune and HPA axis response.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared to the saline\u2010treated control rats, dexamethasone\u2010treated rats had significantly less periodontal bone loss (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01), reduced expression of glucocorticoid receptors in the hippocampus (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001), lower corticosterone (<jats:italic>p<\/jats:italic>\u2003=\u20030.01) and higher plasma levels of the cytokine tumor necrosis factor (TNF)\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05) after LPS challenge. Also the tianeptine\u2010treated rats showed significantly reduced periodontal bone loss (<jats:italic>p<\/jats:italic>\u2003=\u20030.01), enhanced plasma levels of TNF\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), and transforming growth factor\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01), whereas no significant difference was found in corticosterone levels.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> An individual's responsiveness to danger signals, whether they are of immunological, chemical, or psychological origin, may be an important factor for explaining variability in susceptibility to periodontal disease. The results may provide new insight into the mechanisms of periodontal disease development, and open new vistas for disease prevention.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2005.00833.x","type":"journal-article","created":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T17:54:13Z","timestamp":1132595653000},"page":"23-32","source":"Crossref","is-referenced-by-count":35,"title":["Neonatal dexamethasone and chronic tianeptine treatment inhibit ligature\u2010induced periodontitis in adult 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