{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:22:04Z","timestamp":1773274924367,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T00:00:00Z","timestamp":1147737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Recent studies have shown that bone morphogenetic protein\u20102 (BMP\u20102) stimulates mineralization and osteoclast differentiation. Osteoclastic resorption by BMP\u20102 application may play an important role in the regulation of new cementum\u2010like tissue formation on the dentin surfaces. Therefore, this study aimed to examine the effect of BMP\u20102 application on dentin resorption and cementum\u2010like tissue formation at the dentin surfaces.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Seventy\u2010two flat dentin blocks were prepared from rat roots and treated with 24% EDTA. Each block was assigned to group 0, group 100, or group 400, and immersed correspondingly in 0, 100, or 400\u2003\u00b5g\/ml BMP\u20102. The dentin blocks were then implanted into palatal connective tissue of rats, and specimens were prepared 2, 4 and 8\u2003wk after surgery for histologic and histomorphometric analyses.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> BMP\u20102 caused a dose\u2010dependent increase in dentin resorption by osteoclastic cells. New cementum\u2010like tissue was randomly formed on parts of the nonresorbed and resorbed dentin surfaces in groups 100 and 400. Dentin resorption in groups 100 and 400 was significantly greater than group 0 (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01). However, at 8\u2003wk, new cementum\u2010like tissue formed in 41.8% of group 100, as compared with 16.2% of group 400 (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Dentin resorption was stimulated by a high dose of BMP\u20102, and cementum\u2010like tissue was induced by a low dose of BMP\u20102, effectively suggesting that BMP\u20102 application, at an appropriate dose, to a dentin surface may enhance periodontal regeneration.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00878.x","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T10:48:55Z","timestamp":1147776535000},"page":"311-315","source":"Crossref","is-referenced-by-count":36,"title":["Dentin resorption and cementum\u2010like tissue formation by bone morphogenetic protein 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