{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:53Z","timestamp":1790912873853,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:00:00Z","timestamp":1152144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background and Objective:\u2002<\/jats:bold>\n                    With current periodontal diagnostic tools it is difficult to identify susceptible individuals or sites at risk. The aim of this study was to evaluate the efficacy of the matrix metalloproteinase (MMP)\u20108\u2010specific chair\u2010side dip\u2010stick test in longitudinally monitoring the periodontal status of smoking (S) and nonsmoking (NS) patients with chronic periodontitis, using their gingival crevicular fluid (GCF) MMP\u20108 concentrations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and Methods:\u2002<\/jats:bold>\n                    Clinical parameters, MMP\u20108 test results and concentrations were monitored in 16 patients after initial treatment and in 15 patients after scaling and root planing (SRP), every other month, over a 12\u2010mo time period. Progressing and stable sites, and sites with exceptionally high MMP\u20108 concentrations, were analysed in smokers and nonsmokers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    SRP reduced the mean GCF MMP\u20108 levels, test scores, probing depth (PD), attachment loss (AL) and bleeding on probing (BOP). In sites of periodontal disease progression, the distribution of MMP\u20108 concentrations was broader than in stable sites, indicating a tendency for elevated concentrations in patients with periodontal disease. The mean MMP\u20108 concentrations in smokers were lower than in nonsmokers, but in smokers' and nonsmokers' sites with progressive disease, MMP\u20108 concentrations were similar. Sites with exceptionally elevated MMP\u20108 concentrations were clustered in smokers who also showed a poor response to SRP. In these sites, the MMP\u20108 concentration did not decrease with SRP and these sites were easily identified by the MMP\u20108 test.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Persistently elevated GCF MMP\u20108 concentrations may indicate sites at risk, as well as patients with poor response to conventional periodontal treatment (e.g. SRP). MMP\u20108 testing may be useful as an adjunct to traditional periodontal diagnostic methods during the maintenance phase.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00897.x","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T06:12:03Z","timestamp":1152166323000},"page":"503-512","source":"Crossref","is-referenced-by-count":114,"title":["Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase\u20108\u2010specific chair\u2010side 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