{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:19:34Z","timestamp":1762503574944},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Inflammatory cytokines are thought to trigger periodontal tissue destruction. In addition to being regulated by anti\u2010inflammatory mediators, their activity is under the control of suppressors of cytokine signaling (SOCS), which down\u2010regulate the signal transduction as part of an inhibitory feedback loop. We therefore investigated the expression of SOCS\u20101, \u20102 and \u20103, and the cytokines tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u201010, in different forms of human periodontal diseases.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Quantitative polymerase chain reaction (RealTime\u2010PCR) was performed with mRNA from gingival biopsies of control subjects and from that of patients with chronic gingivitis and chronic periodontitis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Our results show that patients with chronic gingivitis and chronic periodontitis exhibit significantly higher SOCS\u20101, \u20102 and \u20103, TNF\u2010\u03b1 and interleukin\u201010 mRNA expression when compared with healthy controls. The data also demonstrate that SOCS\u20101 and \u20103 mRNA expression was higher in tissue from patients with chronic gingivitis than chronic periodontitis, while the levels of SOCS\u20102, TNF\u2010\u03b1 and interleukin\u201010 mRNA were similar in these groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The increased expression of SOCS\u20101, \u20102 and \u20103 mRNA in diseased periodontal tissues is believed to be involved in the down\u2010regulation of inflammatory cytokine and Toll\u2010like receptor signaling, and therefore in the attenuation of both the inflammatory reaction and disease severity. Furthermore, it is possible that variation in the levels of SOCS mRNA expressed in different forms of periodontal diseases may determine the stable or progressive nature of the lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00908.x","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T13:12:50Z","timestamp":1158930770000},"page":"580-584","source":"Crossref","is-referenced-by-count":54,"title":["Expression of suppressors of cytokine signaling in diseased periodontal tissues: a stop signal for disease progression?"],"prefix":"10.1111","volume":"41","author":[{"given":"G. P.","family":"Garlet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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