{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:59:30Z","timestamp":1777539570670,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Gingival overgrowth is a side\u2010effect of nifedipine and cyclosporin medications. Integrins are transmembrane glycoproteins that mediate cell adhesion, regulate cell proliferation and participate in the regulation of tissue fibrosis. The aim of this study was to investigate whether expression of epithelial cell integrins is linked to the development of drug\u2010induced gingival overgrowth.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Human gingival biopsies of patients taking nifedipine, cyclosporin, or a combination of both medications, were used. Expression of the \u03b15\u03b21, \u03b1v\u03b21 and \u03b1v\u03b26 integrins, and of cellular extra domain A of fibronectin, was localized in frozen sections using immunohistochemistry.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The activated conformation of the \u03b21, \u03b15\u03b21 and \u03b1v\u03b26 integrins were more frequently expressed in distinct locations in the oral epithelium in the combined drug group. Cellular extra domain A of fibronectin, a ligand for both \u03b15\u03b21 and \u03b1v\u03b26 integrins, was expressed within the connective tissue of all groups. It was also expressed around the basal keratinocytes of the control, nifedipine and cyclosporin\u2010induced gingival overgrowth groups, but not in the combined medication group. No relationship between the presence of inflammation and integrin expression was found.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results indicate that expression of certain integrins is up\u2010regulated in the epithelium of drug\u2010induced gingival overgrowth where they could participate in controlling the formation of elongated rete ridges and tissue fibrosis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00927.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T06:16:45Z","timestamp":1166681805000},"page":"144-151","source":"Crossref","is-referenced-by-count":13,"title":["Expression of fibronectin\u2010binding integrins in gingival epithelium in drug\u2010induced gingival overgrowth"],"prefix":"10.1111","volume":"42","author":[{"given":"P.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"H\u00e4kkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pernu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Knuuttila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Larjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.63"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004217.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199345060-00007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90327-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.9.639"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1995.tb00160.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.167"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10112.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240107.x"},{"key":"e_1_2_6_11_2","first-page":"42","volume-title":"Cell Invasion","author":"Larjava H","year":"2002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116719"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800712"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.548"},{"key":"e_1_2_6_16_2","volume-title":"A Textbook of Oral Pathology","author":"Shafer WG","year":"1983"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.5.1548"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.6.1755"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1016\/S0021-9258(18)68822-2","article-title":"Transforming growth factor \u03b2 stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts","volume":"263","author":"Roberts CJ","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.19.11067"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1016\/S0021-9258(17)37465-3","article-title":"Role of integrin \u03b1v\u03b26 in cell attachment to fibronectin. 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