{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:40Z","timestamp":1760888020561},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T00:00:00Z","timestamp":1170720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The aim of this study was to identify the expression of cyclooxygenase\u20101, cyclooxygenase\u20102, cyclooxygenase\u20103, and microsomal prostaglandin E synthase\u20101 in young and elderly subjects.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Periodontally healthy subjects were divided into young (18\u201330\u2003years, <jats:italic>n<\/jats:italic> = 7) and elderly (46\u201377\u2003years, <jats:italic>n<\/jats:italic> = 7). A gingival biopsy was taken at baseline. After experimental gingivitis, clinical examination was repeated and a second biopsy was taken. The expression of cyclooxygenase\u20101, cyclooxygenase\u20102, cyclooxygenase\u20103, and microsomal prostaglandin E synthase\u20101 was analyzed by means of immunohistochemistry.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In both healthy age groups, cyclooxygenase\u20101 and microsomal prostaglandin E synthase\u20101 were expressed in epithelial cells, endothelial cells and fibroblast\u2010like connective tissue cells. Cyclooxygenase\u20101 was found in Langerhans' cells of the epithelium. Cyclooxygenase\u20102 expression was observed in cells exhibiting the morphology of epithelial mitosis cells, and the expression of cyclooxygenase\u20102 in periodontally healthy elderly subjects was significantly lower (<jats:italic>p<\/jats:italic>\u2003\u2264\u20030.05). Following experimental gingivitis, cyclooxygenase\u20101 and microsomal prostaglandin E synthase\u20101 expression did not change. However, the expression of cyclooxygenase\u20102 was significantly increased in both age groups (<jats:italic>p<\/jats:italic>\u2003\u2264\u20030.05). Cyclooxygenase\u20103 was not detected in any group investigated.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Cyclooxygenase\u20101 and microsomal prostaglandin E synthase\u20101 were expressed constitutively in gingival tissue, and expression was unaffected by age or inflammation states. In contrast, the expression of cyclooxygenase\u20102 was weaker in elderly subjects. In the course of experimental gingivitis, cyclooxygenase\u20102 was induced in both age groups.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00942.x","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T11:50:48Z","timestamp":1170762648000},"page":"259-266","source":"Crossref","is-referenced-by-count":7,"title":["The effect of age on prostaglandin\u2010synthesizing enzymes in the development of gingivitis"],"prefix":"10.1111","volume":"42","author":[{"given":"B.","family":"Siegel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Weihe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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