{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:31:15Z","timestamp":1790184675812,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Diabetes is associated with an increased risk for vascular disease and periodontitis. The aim of this study was to assess the effects of periodontal treatment in diabetes with respect to alterations in the pro\u2010inflammatory potential of peripheral blood mononuclear cells.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Ten patients with diabetes and moderate to severe periodontitis received full\u2010mouth subgingival debridement. Blood samples for serum\/plasma and mononuclear cell isolation were collected prior to and 4\u2003wk after therapy. Mononuclear cells were analyzed by flow cytometry and stimulated with lipopolysaccharide or ionomycin\/phorbol ester to determine the pro\u2010inflammatory capacity of macrophages and lymphocytes, respectively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Following periodontal treatment, all patients demonstrated a significant improvement in clinical periodontal status (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), despite only modest reduction in subgingival bacterial load or homologous serum immunoglobulin G titers. CD14<jats:sup>+<\/jats:sup> blood monocytes decreased by 47% (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), and the percentage of macrophages spontaneously releasing tumor necrosis factor\u2010\u03b1 decreased by 78% (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05). There were no significant changes in the capacity of lymphocytes to secrete interferon\u2010\u03b3. Among a number of serum inflammatory markers tested, high\u2010sensitivity\u2010C\u2010reactive protein significantly decreased by 37% (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01) and soluble E\u2010selectin decreased by 16.6% (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These data suggest a reduced tendency for monocyte\/macrophage\u2010driven inflammation with periodontal therapy and a potential impact on atherosclerosis\u2010related complications in diabetic individuals.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00945.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T15:57:24Z","timestamp":1169740644000},"page":"274-282","source":"Crossref","is-referenced-by-count":56,"title":["Effects of periodontal therapy on serum C\u2010reactive protein, sE\u2010selectin, and tumor necrosis factor\u2010\u03b1 secretion by peripheral blood\u2010derived macrophages in diabetes. 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