{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:23:47Z","timestamp":1789950227183,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:00:00Z","timestamp":1175212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> This study evaluated whether the biochemical changes associated with type 2 diabetes modulate the expression of interleukin\u20101\u03b2, interleukin\u20106, interleukin\u20108, and interferon\u2010\u03b3 in sites with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Biopsies were harvested and divided into three groups: group 1, systemically and periodontally healthy subjects (<jats:italic>n<\/jats:italic>\u2003=\u200310); group 2, systemically healthy subjects with moderate\u2010to\u2010severe chronic periodontitis (probing depth &gt; 6\u2003mm) (<jats:italic>n<\/jats:italic>\u2003=\u200320); and group 3, type 2 diabetic subjects with periodontitis (<jats:italic>n<\/jats:italic>\u2003=\u200320). Cytokine levels were assessed in the gingival tissues by enzyme\u2010linked immunosorbent assay analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Data analysis demonstrated that the interleukin\u20101\u03b2, interleukin\u20106, interleukin\u20108, and interferon\u2010\u03b3 levels were higher in the presence of periodontal inflammation than in the absence of inflammation, regardless of systemic status. The interleukin\u20101\u03b2 and interleukin\u20106 levels were higher in diabetic subjects (group 3) than in systemically healthy patients with comparable types of periodontitis (group 2). No difference was observed for the interleukin\u20108 and interferon\u2010\u03b3 levels between groups 2 and 3.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Within the limits of this study, it was concluded that type 2 diabetes was associated with increased expression of interleukin\u20101\u03b2 and interleukin\u20106 in periodontally inflamed tissues of diabetic patients, relative to nondiabetic subjects, and that such overexpression may be involved in the mechanisms by which type 2 diabetes enhances periodontal destruction.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00961.x","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T09:03:10Z","timestamp":1175245390000},"page":"377-381","source":"Crossref","is-referenced-by-count":55,"title":["Overexpression of interleukin\u20101\u03b2 and interleukin\u20106 may play an important role in periodontal breakdown in type 2 diabetic patients"],"prefix":"10.1111","volume":"42","author":[{"given":"P. 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