{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:15:53Z","timestamp":1780676153777,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> \u03b2\u2003defensin antimicrobial peptides are important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. The aims of this study were to determine the mRNA expression of human \u03b2\u200adefensin\u20101 and \u20102 in the gingival tissue of patients with gingivitis, aggressive periodontitis and chronic periodontitis, and to evaluate the relationship between defensin expression and type and\/or severity of periodontal destruction.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Fifteen patients in each group with gingivitis, aggressive periodontitis and chronic periodontitis, and 10 healthy subjects, were included in the study (<jats:italic>n<\/jats:italic>\u2003=\u200355). The periodontal status of the subjects was determined by periodontal clinical measurements and radiographical evaluations. Transcriptional levels of human \u03b2\u200adefensin\u20101 and \u20102 genes in gingival samples were assessed by using the quantitative real\u2010time polymerase chain reaction technique, and the data were evaluated statistically by the <jats:sc>relative expression<\/jats:sc> Software Tool 2 for groupwise comparisons.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Expression of the human \u03b2\u200adefensin\u20101 gene was lower in gingivitis and aggressive periodontitis groups, and significantly higher in the chronic periodontitis group, than in the control group (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001). Human \u03b2\u200adefensin\u20102 mRNA expression in the gingivitis group was lower than in the control group; however, the difference was statistically significant only in half of the gingivitis patients (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001). Human \u03b2 defensin\u20102 mRNA levels were higher in some chronic periodontitis patients, but lower in the others when compared with the control group (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001). Expression of the human \u03b2\u200adefensin\u20102 gene increased in the aggressive periodontitis group relative to the control group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study suggests that human \u03b2 defensin\u20101 and \u20102 genes in the gingival epithelium show differential expression in patients with specific periodontal diseases, and aggressive and chronic periodontitis types demonstrate different gingival \u03b2\u200adefensin\u20101 and \u20102 expression patterns.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2006.00964.x","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T16:31:50Z","timestamp":1173457910000},"page":"429-437","source":"Crossref","is-referenced-by-count":52,"title":["Human \u03b2\u200adefensin\u20101 and \u20102 expression in the gingiva of patients with specific periodontal diseases"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Vardar\u2010Sengul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. H.","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Erkizan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kurulgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Baylas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00171-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5437.113"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090040201"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.3.9070620"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(01)00442-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7886453"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.2740-2745.1999"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00727.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2907-2915.2000"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1128\/IAI.66.9.4222-4228.1998","article-title":"Expression of the peptide antibiotic human \u03b2 defensin 1 in cultured gingival epithelial cells and gingival tissue","volume":"66","author":"Krisanaprakornkit S","year":"1998","journal-title":"Infect Immun"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360503.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_6_15_2","first-page":"905","article-title":"Motivation and instruction","volume":"85","author":"Saxer UP","year":"1975","journal-title":"Schweiz Monatschr Zahnheilk"},{"key":"e_1_2_6_16_2","first-page":"1030","article-title":"Mechanical stimulation of 3t3 fibroblasts activates genes: itgb5 and p53 responses as quantified on the mRNA level","volume":"2","author":"Demirci T","year":"2004","journal-title":"Biomed Tech (Berl)"},{"key":"e_1_2_6_17_2","first-page":"1046","article-title":"Mechanical stimulation of 3t3 fibroblasts activates genes: Real Time PCR products and suppliers by comparison","volume":"2","author":"Demirci T","year":"2004","journal-title":"Biomed Tech (Berl)"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300305.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.9.e36"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2410"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81895-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.352-358.2004"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1994.tb01209.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00480-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.4049\/jimmunol.163.12.6718","article-title":"Expression and regulation of human beta defensins hBD\u20101 and hBD\u20102 in intestinal epithelium","volume":"163","author":"O'Neil DA","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02454.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.575"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00211.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.316"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5165"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2006.00964.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2006.00964.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:23:04Z","timestamp":1696965784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2006.00964.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,13]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0765.2006.00964.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2006.00964.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,13]]}}}