{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:34:35Z","timestamp":1783636475212,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T00:00:00Z","timestamp":1185840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold>  <jats:italic>Porphyromonas gingivalis<\/jats:italic> fimbriae play a key role in colonization of the oral cavity. The <jats:italic>fimA<\/jats:italic> gene, which encodes fimbrillin (<jats:italic>FimA<\/jats:italic>), can be classified into six types (I\u2013V and Ib) according to nucleotide sequence. In the present study, we investigated the relationship between the prevalence of <jats:italic>P.\u2003gingivalis<\/jats:italic>\u2010specific <jats:italic>fimA<\/jats:italic> genotypes and periodontal health status in Chinese adults.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> One\u2010hundred and fifteen patients with chronic periodontitis and 136 periodontally healthy adults were selected. <jats:italic>P.\u2003gingivalis<\/jats:italic> detection, determination of <jats:italic>fimA<\/jats:italic> genotypes, <jats:italic>and<\/jats:italic> the co\u2010existence of <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> with various <jats:italic>fimA<\/jats:italic> types, were assessed by the polymerase chain reaction. Odds ratios and 95% confidence intervals were calculated for associating the <jats:italic>fimA<\/jats:italic>\u2010specific genes with periodontitis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>P.\u00a0gingivalis<\/jats:italic> was detected in 22.1% of healthy subjects and in 81.7% of the patients. A single <jats:italic>fimA<\/jats:italic> genotype was detected in most samples. In healthy adults, the most prevalent <jats:italic>fimA<\/jats:italic> genotype was type I (66.7%). However, type II was detected most frequently (43.6%) in the patient group, followed by type IV (30.9%). The frequency of co\u2010existing <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>T.\u2003forsythia<\/jats:italic> was highest in type II <jats:italic>fimA<\/jats:italic>\u2010positive sites. Statistical analysis revealed that periodontitis was associated with occurrences of type I (odds ratio 0.97), Ib (odds ratio 13.26), II (odds ratio 36.62), III (odds ratio 4.57), IV (odds ratio 22.86) and V (odds ratio 1.19).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>  <jats:italic>P.\u2003gingivalis<\/jats:italic> type II followed by type IV were considered as disease\u2010associated strains that account for the pathogenesis of chronic periodontitis in Chinese adults.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.00975.x","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T11:01:44Z","timestamp":1185879704000},"page":"511-517","source":"Crossref","is-referenced-by-count":56,"title":["Prevalence of <i>fimA<\/i> genotypes of <i>Porphyromonas gingivalis<\/i> and periodontal health status in Chinese 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