{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:37:39Z","timestamp":1771231059808,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T00:00:00Z","timestamp":1186963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Chronic periodontitis is an inflammatory disease caused by bacteria in subgingival pockets. Because Toll\u2010like receptor 2 and Toll\u2010like receptor 4 have been shown to play an important role in the recognition of periodontal pathogens, we investigated the relevance of genetic variations in <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic> to susceptibility to periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> A total of 97 patients with chronic periodontitis and 100 control subjects were examined for mutations in <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic>. Case\u2010control analysis was performed using individual single nucleotide polymorphisms detected during the mutation search.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The missense mutations reported previously in <jats:italic>TLR2<\/jats:italic> (677 Arg&gt;Trp and 753 Arg&gt;Gln) and in <jats:italic>TLR4<\/jats:italic> (299 Asp&gt;Gly and 399 Thr&gt;Ile) were not detected in 97 of the Japanese patients with chronic periodontitis or in 100 of the Japanese control subjects. Nine single nucleotide polymorphisms were identified in exons of <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic>. The case\u2010control analysis revealed that the frequency of the C\/C genotype at base\u2010pair position +3725 in <jats:italic>TLR4<\/jats:italic> was significantly higher in both the moderate and the severe periodontitis patient group than in the control group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> A genetic variation of <jats:italic>TLR4<\/jats:italic> might be associated with moderate and severe periodontitis in the Japanese population.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.00979.x","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T18:15:26Z","timestamp":1187288126000},"page":"541-545","source":"Crossref","is-referenced-by-count":52,"title":["Evidence for association between a Toll\u2010like receptor 4 gene polymorphism and moderate\/severe periodontitis in the Japanese 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