{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:30:06Z","timestamp":1777120206343,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Interleukin\u201010 has been described as an anti\u2010inflammatory cytokine and a B\u2010cell proliferation factor. Promoter polymorphisms of the interleukin\u201010 gene have been associated with altered interleukin\u201010 expression. Therefore, the aim of this study was to evaluate three polymorphisms at positions \u22121082G&gt;A, \u2212819C&gt;T and \u2212590C&gt;A in patients with generalized chronic periodontitis (<jats:italic>n<\/jats:italic>\u2003=\u200327) and generalized aggressive periodontitis (<jats:italic>n<\/jats:italic>\u2003=\u200332) in comparison with periodontitis\u2010free controls (<jats:italic>n<\/jats:italic>\u2003=\u200334).<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Interleukin\u201010 promoter polymorphisms were analyzed by polymerase chain reaction with sequence\u2010specific primers (PCR\u2010SSP). Distributions of single alleles, genotypes and haplotypes were calculated by the chi\u2010square test. Risk factor analyses were carried out by logistic regression. Subgingival bacteria were subjected to molecular biological analyses using the micro\u2010Ident<jats:sup>\u00ae<\/jats:sup> test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The combination ATA\/ATA was found only in patients with aggressive periodontitis (15.6 vs. 0.0%, <jats:italic>p<\/jats:italic>\u2003=\u20030.023). Taking into account age, gender, smoking and plaque level, an increased odds ratio (3.7, <jats:italic>p<\/jats:italic>\u2003=\u20030.04) for aggressive periodontitis was shown for subjects with the haplotype ATA. <jats:italic>Prevotella intermedia<\/jats:italic> was found to be decreased in ACC\u2010 positive (41.3 vs. 66.7%, <jats:italic>p<\/jats:italic>\u2003=\u20030.022), ATA\u2010positive (33.3 vs. 57.1%, <jats:italic>p<\/jats:italic>\u2003=\u20030.032) and ACC\/ATA\u2010positive (20.0 vs. 55.9%, <jats:italic>p<\/jats:italic>\u2003=\u20030.002) individuals. In GCC\/GCC\u2010positive subjects, <jats:italic>P.\u2003intermedia<\/jats:italic> occurred more frequently (86.7 vs. 42.3%, <jats:italic>p<\/jats:italic>\u2003=\u20030.002).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The haplotype ATA, which is known as a \u2018low interleukin\u201010 producer\u2019 is a putative risk indicator for generalized aggressive periodontitis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.00992.x","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T10:23:52Z","timestamp":1179743032000},"page":"40-47","source":"Crossref","is-referenced-by-count":54,"title":["The interleukin\u201010 promoter haplotype ATA is a putative risk factor for aggressive periodontitis"],"prefix":"10.1111","volume":"43","author":[{"given":"S.","family":"Reichert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. K. 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